Curriculum Vitae

PERSONAL DETAILS

Dr Looi Chung Yeng


ADMINISTRATIVE DUTIES
(Role),(Level),(Duration)
  • Senior Lecturer I, Faculty of Health & Medical Sciences, 07/08/2017 to present
ACADEMIC QUALIFICATION
(Qualification),(Institution)
  • PhD in Medical Sciences, TOHOKU UNIVERSITY JAPAN, Japan
  • Master of Science (Medical Sciences), TOHOKU UNIVERSITY JAPAN, Japan
  • Bachelor of Science (Hons) Biomedical Sciences, UNIVERSITY PUTRA MALAYSIA, Malaysia
PROFESSIONAL QUALIFICATION
(Qualification),(Institution)
  • Post-Graduate Certificate Teaching and Learning, TAYLOR'S UNIVERSITY SDN BHD, -
AREAS OF EXPERTISE
(Area)
  • Molecular Pharmacology (Drug design, Drug discovery, Cell therapy, Cancer, Infectious diseases)
RESEARCH INTEREST
(Research Area)
  • Elucidating drug targets and mechanism of action by using cell-line and animal models Evaluation of natural/synthetic compounds for anti-cancer and anti-inflammatory activities Understanding carcinogenesis and immunological disorders using molecular and biochemical analyses Explore novel interventions in cancer and immunological disorders
TEACHING
(Course Title),(Level of Study),(Institution),(Month/Year)
  • Pharmacology, Bachelor Degree, Taylor's University (08/2017)
PUBLICATIONS
(Title of publication in APA style)
Book Chapter
2017
  • Neama, A. F., Looi, C. Y., Wong W. F. (2017) Lymphocyte Updates-Cancer, Autoimmunity and Infection. http://dx.doi.org/10.5772/intechopen.68869
Article in Journals
2019
  • Loh, C-Y., Arya, A.,Naema, A.F., Wong, WF., Sethi, G., Looi, CY. (2019) Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication. Front. Oncol. | doi: 10.3389/fonc.2019.00048
2018
  • Hematpoor, A., Paydar, M., Liew, S. Y., Sivasothy, Y., Mohebali, N., Looi, C. Y., . . . Awang, K. (2018). Phenylpropanoids isolated from Piper sarmentosum Roxb. induce apoptosis in breast cancer cells through reactive oxygen species and mitochondrial-dependent pathways. Chem Biol Interact, 279, 210-218. doi: 10.1016/j.cbi.2017.11.014 (ISI-Indexed)
  • Siriviriyanun A, Tsai YJ, Voon SH, Kiew SF, Imae T, Kiew LV, Looi CY, Wong WF, Lee HB, Chung LY. (2018). Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents, Materials Science and Engineering: C, 89, 307-315. (ISI-Indexed)
  • Laevifins A-G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. (ISI-Indexed)
2017
  • Chai, H. J., Kiew, L. V., Chin, Y., Norazit, A., Mohd Noor, S., Lo, Y. L., . . . Chung, L. Y. (2017). Renal targeting potential of a polymeric drug carrier, poly-l-glutamic acid, in normal and diabetic rats. Int J Nanomedicine, 12, 577-591. doi: 10.2147/IJN.S111284 (ISI-Indexed)
  • Hasanpourghadi, M., Looi, C. Y., Pandurangan, A. K., Sethi, G., Wong, W. F., & Mustafa, M. R. (2017). Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review. Curr Drug Targets, 18(9), 1086-1094. doi: 10.2174/1389450117666160401124842 (ISI-Indexed)
  • Dai, X., Wang, L., Deivasigamni, A., Looi, C. Y., Karthikeyan, C., Trivedi, P., . . . Sethi, G. (2017). A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget, 8(8), 12831-12842. doi: 10.18632/oncotarget.14606 (ISI-Indexed)
  • Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems (ISI-Indexed)
  • Applications of deep eutectic solvents in biotechnology and bioengineering-Promises and challenges (ISI-Indexed)
  • Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma (ISI-Indexed)
  • Corrigendum: Apoptotic effect of novel Schiff Based CdCl2(C14H21N3O2) complex is mediated via activation of the mitochondrial pathway in colon cancer cells. (ISI-Indexed)
  • Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells (ISI-Indexed)
2016
  • Aydin Tekdas, D., Viswanathan, G., Zehra Topal, S., Looi, C. Y., Wong, W. F., Min Yi Tan, G., . . . Dumoulin, F. (2016). Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains. Org Biomol Chem, 14(9), 2665-2670. doi: 10.1039/c5ob02477c (ISI-Indexed)
  • Hayyan, M., Mbous, Y. P., Looi, C. Y., Wong, W. F., Hayyan, A., Salleh, Z., & Mohd-Ali, O. (2016). Natural deep eutectic solvents: cytotoxic profile. Springerplus, 5(1), 913. doi: 10.1186/s40064-016-2575-9 (ISI-Indexed)
  • Hasanpourghadi, M., Karthikeyan, C., Pandurangan, A. K., Looi, C. Y., Trivedi, P., Kobayashi, K., . . . Mustafa, M. R. (2016). Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell. J Exp Clin Cancer Res, 35, 58. doi: 10.1186/s13046-016-0332-0 (ISI-Indexed)
  • Koosha, S., Alshawsh, M. A., Looi, C. Y., Seyedan, A., & Mohamed, Z. (2016). An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. Int J Med Sci, 13(5), 374-385. doi: 10.7150/ijms.14485 (ISI-Indexed)
  • Leong, K. H., Looi, C. Y., Loong, X. M., Cheah, F. K., Supratman, U., Litaudon, M., . . . Awang, K. (2016). Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line. PLoS One, 11(4), e0152652. doi: 10.1371/journal.pone.0152652 (ISI-Indexed)
  • Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification (ISI-Indexed)
  • Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells (ISI-Indexed)
  • Acylphenols and dimeric acylphenols from Myristica maxima Warb (ISI-Indexed)
  • Triclosan Demonstrates Synergic Effect with Amphotericin B and Fluconazole and Induces Apoptosis-Like Cell Death in Cryptococcus neoformans (ISI-Indexed)
  • Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds (ISI-Indexed)
  • Erratum: prevalence of plasmid-bearing and plasmid-free chlamydia trachomatis infection among women who visited obstetrics and gynecology clinics in Malaysia (ISI-Indexed)
  • Prevalence of plasmid-bearing and plasmid-free Chlamydia trachomatis infection among women who visited obstetrics and gynecology clinics in Malaysia (ISI-Indexed)
  • Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets (ISI-Indexed)
2015
  • Ahmadipour, F., Noordin, M. I., Mohan, S., Arya, A., Paydar, M., Looi, C. Y., . . . Kamalidehghan, B. (2015). Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study. Drug Des Devel Ther, 9, 1193-1208. doi: 10.2147/DDDT.S72127 (ISI-Indexed)
  • Ananda Sadagopan, S. K., Mohebali, N., Looi, C. Y., Hasanpourghadi, M., Pandurangan, A. K., Arya, A., . . . Mustafa, M. R. (2015). Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. J Exp Clin Cancer Res, 34, 147. doi: 10.1186/s13046-015-0266-y (ISI-Indexed)
  • Arya, A., Al-Obaidi, M. M., Karim, R. B., Taha, H., Khan, A. K., Shahid, N., . . . Ali, H. M. (2015). Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves beta-cell function in streptozotocin-nicotinamide induced diabetic rats. J Ethnopharmacol, 175, 229-240. doi: 10.1016/j.jep.2015.08.057 (ISI-Indexed)
  • Hayyan, M., Looi, C. Y., Hayyan, A., Wong, W. F., & Hashim, M. A. (2015). In Vitro and In Vivo toxicity profiling of ammonium-based deep eutectic solvents. PLoS One, 10(2), e0117934. doi: 10.1371/journal.pone.0117934 (ISI-Indexed)
  • Hajrezaie, M., Paydar, M., Looi, C. Y., Moghadamtousi, S. Z., Hassandarvish, P., Salga, M. S., . . . Abdulla, M. A. (2015). Apoptotic effect of novel Schiff based CdCl(2)(C(1)(4)H(2)(1)N(3)O(2)) complex is mediated via activation of the mitochondrial pathway in colon cancer cells. Sci Rep, 5, 9097. doi: 10.1038/srep09097 (ISI-Indexed)
  • Jamali, H., Paydar, M., Ismail, S., Looi, C. Y., Wong, W. F., Radmehr, B., & Abedini, A. (2015). Prevalence, antimicrobial susceptibility and virulotyping of Listeria species and Listeria monocytogenes isolated from open-air fish markets. BMC Microbiol, 15, 144. doi: 10.1186/s12866-015-0476-7 (ISI-Indexed)
  • Liew, S. Y., Khaw, K. Y., Murugaiyah, V., Looi, C. Y., Wong, Y. L., Mustafa, M. R., . . . Awang, K. (2015). Natural indole butyrylcholinesterase inhibitors from Nauclea officinalis. Phytomedicine, 22(1), 45-48. doi: 10.1016/j.phymed.2014.11.003 (ISI-Indexed)
2014
  • Achoui, M., Heyninck, K., Looi, C. Y., Mustafa, A. M., Haegeman, G., & Mustafa, M. R. (2014). Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-kappaB pathways. Drug Des Devel Ther, 8, 1993-2007. doi: 10.2147/DDDT.S68659 (ISI-Indexed)
  • Ahmed Hamdi, O. A., Syed Abdul Rahman, S. N., Awang, K., Abdul Wahab, N., Looi, C. Y., Thomas, N. F., & Abd Malek, S. N. (2014). Cytotoxic constituents from the rhizomes of Curcuma zedoaria. ScientificWorldJournal, 2014, 321943. doi: 10.1155/2014/321943 (ISI-Indexed)
  • Hajrezaie, M., Paydar, M., Moghadamtousi, S. Z., Hassandarvish, P., Gwaram, N. S., Zahedifard, M., . . . Abdulla, M. A. (2014). A Schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway. ScientificWorldJournal, 2014, 540463. doi: 10.1155/2014/540463 (ISI-Indexed)
  • Faraj, F. L., Zahedifard, M., Paydar, M., Looi, C. Y., Abdul Majid, N., Ali, H. M., . . . Abdulla, M. A. (2014). Synthesis, characterization, and anticancer activity of new quinazoline derivatives against MCF-7 cells. ScientificWorldJournal, 2014, 212096. doi: 10.1155/2014/212096 (ISI-Indexed)
  • Liew, S. Y., Looi, C. Y., Paydar, M., Cheah, F. K., Leong, K. H., Wong, W. F., . . . Awang, K. (2014). Subditine, a new monoterpenoid indole alkaloid from bark of Nauclea subdita (Korth.) Steud. induces apoptosis in human prostate cancer cells. PLoS One, 9(2), e87286. doi: 10.1371/journal.pone.0087286 (ISI-Indexed)
  • Aditya Arya, Al-Obaidi, M. M., Shahid, N., Bin Noordin, M. I., Looi, C. Y., Wong, W. F, Mustafa, M. R. (2014). Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study. doi: 10.1016/j.fct.2014.06.010. Food and Chemical Toxicology (ISI-Indexed)
     
2013
  • Gummadi, V. R., Rajagopalan, S., Looi, C. Y., Paydar, M., Renukappa, G. A., Ainan, B. R., . . . Hosahalli, S. (2013). Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode. Bioorg Med Chem Lett, 23(17), 4911-4918. doi: 10.1016/j.bmcl.2013.06.071 (ISI-Indexed)
  • Looi, C. Y., Aditya Arya, Cheah, F. K., Muharram, B., Leong, K. H., Mohamad, K, Mustafa, M. R. (2013). Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. doi: 10.1371/journal.pone.0056643. PLoS One (ISI-Indexed)
     
2012
  • Arbab, I. A., Looi, C. Y., Abdul, A. B., Cheah, F. K., Wong, W. F., Sukari, M. A., . . . Ibrahim Abdelwahab, S. (2012). Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-kappaB Inhibition. Evid Based Complement Alternat Med, 2012, 856029. doi: 10.1155/2012/856029 (ISI-Indexed)
     
  • Arya, A., Looi, C. Y., Cheah, S. C., Mustafa, M. R., & Mohd, M. A. (2012). Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, beta-TC6 and its alleviating role in type 2 diabetic rats. J Ethnopharmacol, 144(1), 22-32. doi: 10.1016/j.jep.2012.08.014 (ISI-Indexed)
  • Aditya Arya*., Cheah, S. C., Looi, C. Y., Taha, H., Mustafa, M. R., & Mohd, M. A. (2012). The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats. doi: 10.1016/j.fct.2012.08.012. Food and Chemical Toxicology (ISI-Indexed)
     
RESEARCH PROJECT
(Project title),(Role),(Duration),(Level)
  • The role of RUNX3 and E-cadherin underlying epithelial to mesenchymal (EMT)-associated cellular plasticity in gastric cancer, Project Leader, 2018 to 2019 (Taylor's University)
  • Copper as target for colorectal cancer therapeutics: Anti-cancer effect of copper (II) complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin, Co-researcher, 2018 to 2019 (Taylor's University)
  • Immunomodulatory and anti-inflammatory effects of Tualang and Kelulut honeys on activated microglial cells, Co-researcher, 2017 to 2019 (Taylor's University)
EVALUATION ACTIVITIES
(Activity),(Duration),(Category)
  • Associate Editor on the BMC Complementary and Alternative Medicine board. To evaluate submitted papers., 2018 to 2020 (Article in Journal)
SUPERVISION
(Title of Thesis),(Name of Candidates),(Academic Level),(Role)
ONGOING
  • LOH CHIN YAP  (Main Supervisor)
  • CHAI JIAN YI  (Main Supervisor)