Curriculum Vitae

PERSONAL DETAILS

Dr Jason Loo Siau Ee


BIOGRAPHY

I graduated with an MPharm from the University of Strathclyde and obtained my PhD (Medicinal Chemistry) from the University of Nottingham before joining Taylor's University School of Pharmacy in 2015. I am also a Board Certified Pharmacotherapy Specialist (BCPS). I currently teach and lead several modules in Clinical Pharmacy and Pharmaceutical Chemistry, and am the currently Program Director for the Bachelor of Pharmacy (Hons) program. I was previously the Student Advisor for the Taylor's University Pharmacy Student Society (TUPSS), which aims to develop student leaders through various events and activities in collaboration with pharmaceutical industry partners and NGOs. I was also previously Associate Dean (International Relations), during which I coordinated international relations and develops student exchange programs with partner universities in Australia, UK, Thailand, and Indonesia. 

My research areas are mainly focused on computational chemistry and molecular modelling of G protein-coupled receptors for structure-based drug design, including homology modelling, molecular dynamics simulations, virtual screening, and free energy calculations. Other research interests include aspects of pharmacy practice and clinical pharmacy. I have been an invited speaker for several CPD workshops for pharmacists, and continue to engage with the profession.

ADMINISTRATIVE DUTIES
(Role),(Level),(Duration)
  • Program Director, School of Pharmacy, 01/06/2020 to present
  • International Affairs Committee, School of Pharmacy, Faculty of Health & Medical Sciences, 01/04/2017 to present
  • Student Advisor, Faculty of Health & Medical Sciences, 01/08/2015 to 01/08/2020
  • Associate Dean (International Relations), Faculty of Health & Medical Sciences, 01/08/2016 to 01/04/2017
ACADEMIC QUALIFICATION
(Qualification),(Institution)
  • Doctor of Philosophy, THE UNIVERSITY OF NOTTINGHAM, -
  • Master of Pharmacy, UNIVERSITY OF STRATHCLYDE GLASGOW, -
PROFESSIONAL MEMBERSHIP
(Organisation),(Role),(Duration),(Level)
  • Board of Pharmacy Specialties, Board Certified Pharmacotherapy Specialist, 2018 to present (International)
  • Malaysian Pharmaceutical Society (MPS), Life member, Since 2016 (National)
AREAS OF EXPERTISE
(Area)
  • Clinical Pharmacy
  • Medicinal Chemistry
  • Drug Discovery
  • Computational Chemistry
PUBLICATIONS
(Title of publication in APA style)
Article in Journals
2023
  • Al-Khdhairawi AAQ, Loo JSE, Mutalib NA, Latip NA, Manshoor N, Abu Bakar H, Shivanagere Nagojappa NB, Weber JF. Diketopiperazine and isoindolinone alkaloids from the endophytic fungus Aspergillus sp. HAB10R1. Phytochemistry, 2023; 211: 113685 (ISI-Indexed)
  • Pan Y, Jagadiah P, Ung YT, Lim SYM, Lim KH, Loo JSE, Pung YF, Chowdhury L and Tao S. Modulatory Effects of Mangiferin Isolated from Aquilaria Plants on Human Cytochrome P450 Enzyme (CYP) Activities in Vitro and in Silico Studies. The Natural Products Journal. 2023; 13
  • Ahmad B, Friar EP, Taylor E, Vohra MS, Serpell CJ, Garrett MD, Loo JSE, Fong IL, Wong EH. Anti-pancreatic lipase and anti-adipogenic effects of 5,7,3′,4′,5’-pentamethoxy and 6,2′,4′-trimethoxy flavone - An in vitro study. European Journal of Pharmacology, 2023;938;175445 (ISI-Indexed)
  • Ahmad B, Friar EP, Vohra MS, Khan N, Serpell CJ, Garrett MD, Loo JSE, Fong IL, Wong EH. Hydroxylated polymethoxyflavones reduce the activity of pancreatic lipase, inhibit adipogenesis and enhance lipolysis in 3T3-L1 mouse embryonic fibroblast cells. Chem. Biol. Interact., 2023;110503 (ISI-Indexed)
  • Loo JSE, Yow HY, Ten YY, Govindaraju K, Megat Mohd Zubairi MH, Oui HC, Abdul Rahim N. Exploring the rise of telehealth services in Malaysia: A retrospective study. Digital Health. 2023;9:1-10 (ISI-Indexed)
  • Ng HL, Sellappans R, Loo JSE. A Survey of the Adoption and Perception of Mobile Health Applications Among Community Pharmacists in Malaysia. Int. J. Pharm. Prac., 2023;31(5):489-495 (SCOPUS-Indexed)
2022
  • Su WS, Thum CM, Loo JSE. An exploratory analysis of general practitioner prescribing patterns in Malaysia using a health insurance claims database. Int. J. Pharm. Prac. 2022;30(1):59-66 (SCOPUS-Indexed)
  • Lim SYM, Loo JSE, Alshagga M, Alshawsh MA, Ong CE, Pan Y. In vitro and In Silico Studies of Interactions of Cathinone with Human Recombinant Cytochrome P450 CYP(1A2), CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, and CYP3A5. Toxicol. Rep. 2022;9:759-768 (SCOPUS-Indexed)
  • Yau MQ, Loo JSE. Consensus scoring evaluated using the GPCR-Bench dataset: Reconsidering the role of MM/GBSA. J. Comput. Aided Mol. Des. 2022
  • Lim SYM, Loo JSE, Alshagga M, Alshawsh MA, Ong CE, Pan Y. Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s. Int. J. Toxicol. 2022
     
2021
  • Francis J, Toh LS, Sellappans R, Loo JSE. Awareness of osteoporosis risk assessment tools and screening recommendations among community pharmacists in Malaysia. Int J Clin Pharm. 2021; 43:604–612 (ISI-Indexed)
  • Lee, Z.Y., Loo, J.S.E., Wibowo, A., Mohammat, M.F. and Foo, J.B. 2021. Targeting Cancer via Golgi α-mannosidase II Inhibition: How Far Have We Come In Developing Effective Inhibitors? Carbohydrate Research (Accepted) (ISI-Indexed)
2020
  • Mok CZ, Sellappans R, Loo JSE. The Prevalence and Perception of Self-medication among Adults in the Klang Valley, Malaysia. Int J Pharm Pract. 2020
  • Yau MQ, Emtage AL, Loo JSE. Benchmarking the performance of MM/PBSA in virtual screening enrichment using the GPCR‑Bench dataset. J. Comput. Aided Mol. Des. 2020. (ISI-Indexed)
  • Loo JSE, Yong AYY, Yong YN. The effect of multiple simulation parameters on MM/PBSA performance for binding affinity prediction of CB1 cannabinoid receptor agonists and antagonists. Chem Biol Drug Des. 2020; 00;1-11 (ISI-Indexed)
2019
  • Loo JSE, Emtage AL, Murali L, Lee SS, Kueh ALW, Alexander SPH. Ligand discrimination during virtual screening of the CB1 cannabinoid receptor crystal structures following cross-docking and microsecond molecular dynamics simulations. RSC Advances. 2019; 9; 15949 - 15956 (ISI-Indexed)
  • Yau MQ, Emtage AL, Chan NJY, Doughty SW, Loo JSE. Evaluating the performance of MM/PBSA for binding affinity prediction using Class A GPCR crystal structures. J. Comput. Aided Mol. Des. 2019; 33(5), 487-496 (ISI-Indexed)
  • Foo JB, Ng LS, Lim JH, Tan PX, Lor YZ, Loo JSE, Low ML, Chan LC, Beh CY, Leong SW, Saiful Yazan L, Tor YS, How CW. Induction of Cell Cycle Arrest and Apoptosis by Copper Complex Cu(SBCM)2 Towards Oestrogen-Receptor Positive MCF-7 Breast Cancer Cells. RSC Adv. 2019; 9(32), 18359-18370 (ISI-Indexed)
  • Foong RTK, Sellappans R, Loo JSE. Awareness of Beers Criteria and knowledge of potentially inappropriate medications among community pharmacists in Malaysia. J. Eval. Clin. Pract. 2019
  • Loo JSE, Lo EMY, Mai CW, Gan PW, Lee EL, Tiong JJL. Separation of prescribing and dispensing in malaysia: Public perception on pharmacists’ roles and agreement towards a separation policy. J. Pharm. Pract. Res. 2019 (In Press)
  • Tan A, Babak MV, Venkatesan G, Lim C, Klotz KN, Herr DR, Cheong SL, Federico S, Spalluto G, Ong WY, Chen YZ, Loo JSE, Pastorin G. Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy. Molecules 2019, 24, 3661 (ISI-Indexed)
2018
  • Loo JSE, Loh MH, Tiong JJL. Utilization of Community Pharmacy Dispensing Services in the Absence of Dispensing Separation: An Evaluation of Prescriptions Dispensed. Indian J. Pharm. Sci., 2018;80.2;390-395 (ISI-Indexed)
  • Loo JSE, Emtage AL, Ng KW, Yong ASJ, Doughty SW. Assessing GPCR homology models constructed from templates of various transmembrane sequence identities: Binding mode prediction and docking enrichment , J. Mol. Graph. Model. 2018 ;80 ; 38-47 (ISI-Indexed)
2017
  • Loo JSE, Lim SW, Ng YK, Tiong JJ. Pharmacy Students in Private Institutions of Higher Education: Motivating Factors When Studying Pharmacy and Influences on University Choice. Int J Pharm Prac 2017. (SCOPUS-Indexed)
2016
  • Tiong J.J.L., Loo J.S.E., Mai C.-W. (2016). Global antimicrobial stewardship: A closer look at the formidable implementation challenges. Frontiers in Microbiology, 7(NOV), pp.- (ISI-Indexed)
Article in Proceeding
2022
  • Ng HL, Sellappans R, Loo JSE (2022). A Survey of the Adoption and Perception of Mobile Health Applications Among Community Pharmacists in Malaysia. Proceedings of 28th Federation of Asian Pharmaceutical Associations, MPS-National Pharmacists Convention 2022. November 10-12, 2022, Kuala Lumpur, Malaysia, Malaysian Journal of Pharmacy 8(2):46-139
2018
  • Yau M, Emtage A and Loo JS (2018). Evaluating the Performance of MM/PBSA for Binding Affinity Prediction Using G Protein-Coupled Receptor Crystal Structures. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00052 (ISI-Indexed)
2017
  • Ng KW, Loo JSE. Evaluating the ability of unbiased molecular dynamics simulations to refine homology models of GPCRs: A case study using the adenosine A2A receptor. The 2nd International Conference on Pharmacy Education and Research Network of ASEAN; 2017 November 21-22, Kuala Lumpur, Malaysia.
  • Loo JSE, Emtage AL, Ng KW, Yong ASJ, Doughty SW. An assessment of G protein-coupled receptor homology models constructed from templates of various transmembrane sequence identities. 13th Malaysian Pharmaceutical Society Scientific Conference; Malaysian Journal of Pharmacy 2017; 3(1);17
Print Media
2018
  • Loo JSE. Common yet overlooked: Non-alcoholic fatty liver disease. MIMS Pharmacy Malaysia. May 2018; 22-28
2016
  • Loo JSE. Management of Insomnia: Making sense of hypnotic choices. MIMS Pharmacy Malaysia. April 2016; 9-11.
RESEARCH PROJECT
(Project title),(Role),(Duration),(Level)
  • Metadynamics simulation-guided design, synthesis and in vitro evaluation of highly selective swainsonine analogues targeting Golgi alpha-mannosidase II as potential anticancer agents in breast, lung, and ovarian cancer., Project Leader, 2021 to 2024 (National)
  • Targeting Alpha-Mannosidase II with Novel Swainsonine Analogues: Potential Anticancer Candidates Acting On Glycosylation Pathways, Co-researcher, 2019 to 2022 (National)
  • Application of MM/PBSA-based methods for the identification of novel leads targeting GPCRs implicated in ageing-related diseases, Project Leader, 2017 to 2021 (Taylor's University)
  • Evaluating the effect of transformation sequence identity on the quality of GPCR homology models, Project Leader, 2016 to 2017 (Taylor's University)
SUPERVISION
(Title of Thesis),(Name of Candidates),(Academic Level),(Role)
ONGOING
  • YAU MEI QIAN  (Main Supervisor)
  • AFIQAH ALI BINTI AJMEL ALI  (Main Supervisor)
COMPLETED
  • APPLICATION OF MM/PBSA-BASED METHODS IN G PROTEIN-COUPLED RECEPTOR DRUG DISCOVERY: BINDING AFFINITY PREDICTION, VIRTUAL SCREENING ENRICHMENT, AND CONSENSUS SCORING, YAU MEI QIAN  (Main Supervisor)