Curriculum Vitae

PERSONAL DETAILS

Dr Tor Yin Sim

  • Senior Lecturer II

  • School of Biosciences
    Faculty of Health & Medical Sciences
  •    03-56295099
  •   yinsim.tor@taylors.edu.my

ADMINISTRATIVE DUTIES
(Role),(Level),(Duration)
  • Lecturer II, Faculty of Health & Medical Sciences, 24/08/2017 to present
ACADEMIC QUALIFICATION
(Qualification),(Institution)
  • Doctor of Philosophy, UNIVERSITI PUTRA MALAYSIA, Malaysia
  • Bachelor of Science (Biomedical Sciences), UNIVERSITI PUTRA MALAYSIA, Malaysia
PROFESSIONAL MEMBERSHIP
(Organisation),(Role),(Duration),(Level)
  • Malaysian Association for Cancer Research (MACR), Associate member, Since 2017 (National)
  • MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, Associate member, 2017 to 2018 (National)
AREAS OF EXPERTISE
(Area)
  • Genetic epidemiology
  • Molecular Pharmacology
PUBLICATIONS
(Title of publication in APA style)
Book Chapter
2023
  • Ooi, D.J., Neo, Y.P., Tor, Y.S., Foo, J.B. (2023). Non-commercial Plant-based Edible Oil for Prevention and Treatment of Chronic Diseases. In Mohan, S, Abdollahi, S. & Pathak, Y.V. (Eds.), Applications of Functional Foods and Nutraceuticals for Chronic Diseases (pp.). CRC Press
Article in Journals
2022
  • Lee, Z.Y., Leong, C.H., Lim, K.U.L., Wong, C.C.S., Pongtheerawan, P., Arikrishnan, S.A., Tan, K.L., Loh, J.S., Low, M.L., How, C.W., Ong, Y.S., Tor, Y.S. and Foo, J.B. 2022. Induction of Apoptosis and Autophagy by Ternary Copper Complex Towards Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry, 22(6): 1159-1170. (ISI-Indexed)
  • Yap, S.K.; Tan, K.L.; Abd Rahaman, N.Y.; Saulol Hamid, N.F.; Ooi, D.J.; Tor, Y.S.; Daniel Looi, Q.H.; Stella Tan, L.K.; How, C.W.; Foo, J.B. Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Insulin Resistance in Type 2 Diabetes Mellitus Rats. Pharmaceutics 2022, 14, 649. https://doi.org/10.3390/pharmaceutics14030649 (ISI-Indexed)
  • Loh, J. S., Rahim, N. A., Tor, Y. S., & Foo, J. B. (2022). Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells. Cell biochemistry and function, 40(4), 403–416. https://doi.org/10.1002/cbf.3704 (ISI-Indexed)
2021
  • Lye MS, Tor YS, Tey YY, Shahabudin A, Loh SP, Ibrahim N, Stanslas J, Rosli R, Ling KH. BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder. J Mol Neurosci. 2021 May;71(5):981-990. doi: 10.1007/s12031-020-01719-0. Epub 2020 Oct 9. PMID: 33034825. (ISI-Indexed)
  • Tan KL, Chia WC, How, CW, Tor, Y.S., Show, P.L., Looi, D.Q.H. and Foo, J.B. 2021. Benchtop Isolation and Characterisation of Small Extracellular Vesicles from Human Mesenchymal Stem Cells. Molecular Biotechnology doi: 10.1007/s12033-021-00339-2. (ISI-Indexed)
  • Arikrishnan, S.A., Loh, J.S., Teo, X.W., Norizan, F.B., Low, M.L., Lee, S.H., Foo, J.B. and Tor, Y.S. 2021. Ternary Copper (II) Complex Induced Apoptosis and Cell Cycle Arrest in Colorectal Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry (Accepted) (ISI-Indexed)
  • Chu Xin Ng, Cheng Foh Le, Yin Sim Tor, Sau Har Lee. (2021). Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways. International Journal of Peptide Research and Therapeutics, https://doi.org/10.1007/s10989-021-10288-8 (ISI-Indexed)
2020
  • Looi, Q.H., Eng, S.P., Laiu, L.L., Tor, Y.S., Baijuri, M.Y., Ng, M.H., Law, J.X. 2020. Mesenchymal stem cell therapy for sports injuries - from research to clinical practice. Sains Malaysiana 49(4)(2020): 825-838. (ISI-Indexed)
  • Lye, M.S., Tey, Y.Y., Tor, Y.S., Shahabudin, A.F., Ibrahim, N, King-Hwa, L., Johnson, S., Su-Peng, L., Rozita, R., Khairul, A.L., Ibrahim, M.B., Asraa, F-A., Nurul, A.A.R. (2020) Predictors of recurrence of major depressive disorder. PLOS ONE 15(3): e0230363. (ISI-Indexed)
  • Lye, M., Tor, Y.S, Tey, Y. et al. (2020) BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder. J Mol Neurosci. In press
2019
  • Isolation of Cardamonin and Pinostrobin Chalcone from the Rhizomes of Boesenbergia rotunda (L.) Mansf. and their Cytotoxic Effects on H-29 and MDA-MB-231 Cancer Cell Lines (SCOPUS-Indexed)
  • Foo JB, Ng LS, Lim JH, Tan PX, Lor YZ, Loo JSE, Low ML, Chan LC, Beh CY, Leong SW, Saiful Yazan L, Tor YS, How CW. Induction of Cell Cycle Arrest and Apoptosis by Copper Complex Cu(SBCM)2 Towards Oestrogen-Receptor Positive MCF-7 Breast Cancer Cells. RSC Adv. 2019; 9(32), 18359-18370 (ISI-Indexed)
  • Aldoghachi AF, Tor YS, Redzun SZ, Lokman KAB, Razaq NAA, Shahbudin AF, Badamasi IM, Cheah PS, Stanslas J, Veerakumarasivam A, Rosli R, Ibrahim N, Lye MS, Ling KH. Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients. PLoS One. 2019 Jan 24;14(1):e0211241. doi: 10.1371/journal.pone.0211241. PMID: 30677092; PMCID: PMC6345459. (ISI-Indexed)
  • Foo SC, Yusoff FM, Imam MU, Foo JB, Ismail N, Azmi NH, Tor YS, Khong NMH, Ismail M. Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathways. Biotechnol Rep (Amst). 2018 Dec 6;21:e00296. doi: 10.1016/j.btre.2018.e00296. PMID: 30581767; PMCID: PMC6296166. (SCOPUS-Indexed)
  • Lye, M. S., Shahbudin, A.-F., Tey, Y. Y., Tor, Y. S., Ling, K. H., Ibrahim, N., Stanslas, J., Loh, S. P. and Rosli, R. (2019) “Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects”, Neuroscience Research Notes, 2(3), pp. 20–28. (SCOPUS-Indexed)
2018
  • Foo, J. B., Lim, J. H., Lor, Y. Z., Zainol, R., Dam, V. E., How, C. W., Low, M. L., Rahman, N. A., Beh, C. Y., Tor, Y. S., Yazan, L. S., 2018. Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell. Biometals. p1-11. (ISI-Indexed)
  • Ong, Y. S., Yazan, L. S., Ng, W. K., Abdullah, R., Mustapha, N. M., Sapuan, S., Foo, J. B., Tor, Y. S., How, C. W., Abd Rahman, N., and Zakarial Ansar, F. H. (2018) Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice. Nanomedicine. 13:13, 1567-1582 (ISI-Indexed)
  • Yazan, L.S., Zainal., N.A., Ali, R.M., Zali, M.F.S.M., Ong, Y.S., Tor, Y.S., Gopalsamy, B., Ling, V.F., Sapuan, S., Esa, N., Haron, A.S., Ansar, F.H.Z., Mokhtar, A.M.A. and Alwi, S.S.S, 2018. Antiulcer properties of kelulut honey against ethanol-induced gastric ulcer. Pertanika Journal of Science and Technology. 26 (1): 121-132.
2016
  • Wan Nor Hafiza, W.A., Yazan, L.S., Tor, Y.S., Foo, J.B., Armania, N. and Rahman, H.S. (2016). Endoplasmic reticulum stress-induced apoptotic pathway and mitochondrial dysregulation in HeLa cells treated with dichloromethane extract of Dillenia suffruticosa, Pharmacognosy Magazine. 12(45): 86-95. (ISI-Indexed)
  • Ong, Y.S., Saiful Yazan, L., Ng, W.K., Noordin, M.M., Sapuan, S., Foo, J.B. and Tor, Y.S. (2016). Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice, International Journal of Nanomedicine. 11: 5905-5915 (ISI-Indexed)
  • Napsiah, A.R. Latifah, S.Y., Wibowo, A., Ahmat, N., Foo, J.B., Tor, Y.S., Yeap, S.K., Razali, Z.A., Ong, Y.S. and Fakurazi, S. (2016). Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231, BMC Complementary and Alternative Medicine 16: Article 354, 11 pages. (ISI-Indexed)
  • Yazan, L.S., Zali, M.F.S.M., Ali, R., Zainal, N.A., Esa, N., Sapuan, S., Ong, Y.S., Tor, Y.S., Gopalsamy, B., Voon, F.L., and Alwi, S.S.S. (2016). Chemopreventive properties and toxicity of kelulut honey in sprague dawley rats induced with azoxymethane, BioMed Research International, 2016: 1-6. (ISI-Indexed)
  • Foo, J.B., Yazan, L.S., Tor, Y.S., Wibowo, A., Ismail, N., Armania, N., Loh, S.P., Ismail, I.S., Cheah, Y.K. and Abdullah, R. (2016). Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells. Journal of Ethnopharmacology, 187: 195-204. (ISI-Indexed)
2015
  • Latifah, S.Y., Ong, Y.S., Zaaba, N.E., Mohd Ali, Razana, Foo, J.B. and Tor, Y.S. (2015). Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice, Asian Pacific Journal of Tropical Biomedicine. 5(12): 1018-1026. (ISI-Indexed)
  • Tor, Y.S., Latifah, S.Y., Foo, J.B., Wibowo, A., Ismail, N., Cheah, Y.K., Abdullah, R., Ismail, M., Ismail, I.S. and Yeap, S.K. (2015). Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa, and its chemical profile. PLoS One, 10(6): e0127441. (ISI-Indexed)
  • Foo, J.B., Yazan, L.S., Tor, Y.S., Wibowo, A., Ismail, N., Armania, N., Loh, S.P., Ismail, I.S., Cheah, Y.K., Abdullah, R. (2015). Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway. Journal of Ethnopharmocology, 166: 270-278. (ISI-Indexed)
2014
  • Foo, J.B., Latifah, S.Y., Tor, Y.S., Armania, N., Ismail, N., Imam, M.U., Yeap, S.K., Cheah, Y.K., Abdullah, R. and Ismail, M. (2014). Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signaling pathways. BMC Complementary and Alternative Medicine, 14: 1-16. IF: 1.88 (ISI-Indexed)
2013
  • Armania, N., Latifah, S.Y., Ismail, I.S., Foo, J.B., Tor, Y.S., Ishak, N., Ismail, N. and Ismail, M. (2013). Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules, 18: 13320-13339 (ISI-Indexed)
2012
  • Hamizah, S., Roslida, A.H., Fezah, O., Tan, K.L., Tor, Y.S. and Tan, C.I. (2012). Chemopreventive potential of Annona muricata L. leaves on chemically-induced skin papillomagenesis in mice. Asian Pacific Journal of Cancer Prevention, 13: 2533-2539. (ISI-Indexed)
RESEARCH PROJECT
(Project title),(Role),(Duration),(Level)
  • Development of human umbilical cord-derived Mesenchymal Stem Cells (hUCB-MSC) and exosomes for the treatment of Diabetes mellitus type 2, Co-researcher, 2019 to 2022 (Private)
  • Targeting Alpha-Mannosidase II with Novel Swainsonine Analogues: Potential Anticancer Candidates Acting On Glycosylation Pathways, Co-researcher, 2019 to 2022 (National)
  • Interferon gamma in regulating Programmed Death-1 Ligand-1 (PD-L1): A prognostic marker in Malaysian non-small cell lung carcinoma (NSCLC), Project Leader, 2019 to 2023 (National)
  • The role of RUNX3 and E-cadherin underlying epithelial to mesenchymal (EMT)-associated cellular plasticity in gastric cancer, Co-researcher, 2018 to 2019 (Taylor's University)
  • Investigating the Role of Autophagy in Breast Cancer Cells Treated with Doxorubicin and Proteasome Inhibitor: Proof of Concept with Autophagy Inhibitor , Co-researcher, 2018 to 2020 (Taylor's University)
  • Copper as target for colorectal cancer therapeutics: Anti-cancer effect of copper (II) complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin, Project Leader, 2018 to 2019 (Taylor's University)
EVALUATION ACTIVITIES
(Activity),(Duration),(Category)
  • Reviewer of International Journal of Peptide Research and Therapeutics, 2022 to 2039 (Article in Journal)
  • Reviewer of BMC Pharmacology and Toxicology, 2022 to 2039 (Article in Journal)
  • Reviewer of BBA - Molecular Cell Research, 2021 to 2039 (Article in Journal)
  • Reviewer of Frontier of Pharmacology, 2021 to 2039 (Article in Journal)
  • Reviewer of BMC Complementary Medicine and Therapies, 2020 to 2039 (Article in Journal)
  • Internal Examiner for Taylor's University Master Student Proposal Defense, 2019 to 2039
SUPERVISION
(Title of Thesis),(Name of Candidates),(Academic Level),(Role)
ONGOING
  • NG CHU XIN  (Co-supervisor (Internal))
  • VITHIYA A/P DEWARAJAN  (Main Supervisor)
  • WONG YONG HUI  (Co-supervisor (Internal))
  • SSARVINNA HARAN A/P MANOHARAN  (Main Supervisor)
COMPLETED
  • ANTI-CANCER EFFECTS OF [CU(PHEN (L-TYR) CL] 3H 2 O IN HT-29 COLORECTAL CANCER CELLS, SATHIAVANI A/P ARIKRISHNAN  (Main Supervisor)
  • LOW DOSE HUMAN MESENCHYMAL STEM CELL-DERIVED SMALL EXTRACELLULAR VESICLE AMELIORATED INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS RATS, TAN KIAN LEONG  (Co-supervisor (Internal))
PRESENTATION
(Title),(Event),(Date Presented),(Organiser),(Level)
ORAL PRESENTER
  • Vitamin D receptor polymorphisms and risk of Major Depressive Disorder. , 29th World Congress of the International Association for Suicide Prevention (IASP) and The 21st Malaysian Conference on Psychological Medicine (MCMP), 18/07/2017 to 22/07/2017, International Association for Suicide Prevention Malaysian Psychiatric Association (International)
POSTER PRESENTER
  • Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa, 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), 06/05/2014 to 08/05/2014, Natural Product Research Center of Excellence, Prince of Songkla Univeristy (International)
AWARDS AND STEWARDSHIP
(Name of Award/Stewardship),(Award Category),(Awarding Institution),(Year Awarded),(Type of Award)
  • Best Paper Award (Third Prize)., Conference, University of Malaya (UM), 2017 (Best Oral)
  • Best Poster Presentation Award, Conference, Universiti Putra Malaysia (UPM), 2014 (Best Poster Award)