Dr Jason Loo Siau Ee

I graduated with an MPharm from the University of Strathclyde and obtained my PhD (Medicinal Chemistry) from the University of Nottingham before joining Taylor's University School of Pharmacy in 2015. I am also a Board Certified Pharmacotherapy Specialist (BCPS). I currently teach and lead several modules in Clinical Pharmacy and Pharmaceutical Chemistry, and am the currently Program Director for the Bachelor of Pharmacy (Hons) program. I was previously the Student Advisor for the Taylor's University Pharmacy Student Society (TUPSS), which aims to develop student leaders through various events and activities in collaboration with pharmaceutical industry partners and NGOs. I was also previously Associate Dean (International Relations), during which I coordinated international relations and develops student exchange programs with partner universities in Australia, UK, Thailand, and Indonesia. 

My research areas are mainly focused on computational chemistry and molecular modelling of G protein-coupled receptors for structure-based drug design, including homology modelling, molecular dynamics simulations, virtual screening, and free energy calculations. Other research interests include aspects of pharmacy practice and clinical pharmacy. I have been an invited speaker for several CPD workshops for pharmacists, and continue to engage with the profession.


Academic Qualification

  • Doctor of Philosophy, THE UNIVERSITY OF NOTTINGHAM, -
  • Master of Pharmacy, UNIVERSITY OF STRATHCLYDE GLASGOW, -

Professional Qualification

No records found

Areas of Expertise

  • Medical And Health Sciences, Pharmacy, Clinical Pharmacy
  • Medical And Health Sciences, Pharmacy, Medicinal Chemistry
  • Medical And Health Sciences, Pharmacy, Drug Discovery
  • Chemical Sciences, Analytical Chemistry, Computational Chemistry

Research Interest

No records found

Publications

2021
  • Awareness of osteoporosis risk assessment tools and screening recommendations among community pharmacists in Malaysia., International Journal of Clinical Pharmacy - Article in Journals
2020
  • The prevalence and perception of self medication among adults in the Klang Valley, Malaysia, International Journal of Pharmacy Practice - Article in Journals
  • Benchmarking the performance of MM/PBSA in virtual screening enrichment using the GPCR Bench dataset. (ISI-Indexed), Journal of Computer-Aided Molecular Design - Article in Journals
  • The effect of multiple simulation parameters on MM/PBSA performance for binding affinity prediction of CB1 cannabinoid receptor agonists and antagonists. (ISI-Indexed), Chemical Biology & Drug Design - Article in Journals
2019
  • Ligand discrimination during virtual screening of the CB1 cannabinoid receptor crystal structures following cross-docking and microsecond molecular dynamics simulations. (ISI-Indexed), RSC Advances - Article in Journals
  • Evaluating the performance of MM/PBSA for binding affinity prediction using Class A GPCR crystal structures. (ISI-Indexed), Journal of Computer-Aided Molecular Design - Article in Journals
  • Induction of Cell Cycle Arrest and Apoptosis by Copper Complex Cu(SBCM)2 Towards Oestrogen-Receptor Positive MCF-7 Breast Cancer Cells. (ISI-Indexed), RSC Advances - Article in Journals
  • Awareness of Beers Criteria and knowledge of potentially inappropriate medications among community pharmacists in Malaysia., Journal of Evaluation in Clinical Practice - Article in Journals
  • Separation of prescribing and dispensing in malaysia: Public perception on pharmacists roles and agreement towards a separation policy., Journal of Pharmacy Practice and Research - Article in Journals
2018
  • Evaluating the Performance of MM/PBSA for Binding Affinity Prediction Using G Protein-Coupled Receptor Crystal Structures (ISI-Indexed) - Article in Proceeding
  • Utilization of Community Pharmacy Dispensing Services in the Absence of Dispensing Separation: An Evaluation of Prescriptions Dispensed. (ISI-Indexed), Indian Journal of Pharmaceutical Sciences - Article in Journals
  • Common yet overlooked: Non-alcoholic fatty liver disease., MIMS Pharmacy Malaysia - Print Media
  • Assessing GPCR homology models constructed from templates of various transmembrane sequence identities: Binding mode prediction and docking enrichment (ISI-Indexed), Journal of Molecular Graphics and Modelling - Article in Journals
2017
  • Pharmacy Students in Private Institutions of Higher Education: Motivating Factors When Studying Pharmacy and Influences on University Choice. (SCOPUS-Indexed), International Journal of Pharmacy Practice - Article in Journals
  • Evaluating the ability of unbiased molecular dynamics simulations to refine homology models of GPCRs: A case study using the adenosine A2A receptor. - Article in Proceeding
  • An assessment of G protein-coupled receptor homology models constructed from templates of various transmembrane sequence identities. - Article in Proceeding
2016
  • Management of Insomnia: Making sense of hypnotic choices., MIMS Pharmacy Malaysia - Print Media
  • Global antimicrobial stewardship: A closer look at the formidable implementation challenges (ISI-Indexed), Frontiers in Microbiology - Article in Journals

Research

  • Targeting Alpha-Mannosidase II with Novel Swainsonine Analogues: Potential Anticancer Candidates Acting On Glycosylation Pathways,  Co-researcher2019 to 2022, National
  • Application of MM/PBSA-based methods for the identification of novel leads targeting GPCRs implicated in ageing-related diseases,  Project Leader2017 to 2021, Taylor's University
  • Evaluating the effect of transformation sequence identity on the quality of GPCR homology models,  Project Leader2016 to 2017, Taylor's University

Awards and Stewardship

No records found

Paper Presented

  • Benchmarking the performance of MM/PBSA in virtual screening enrichment with the GPCR-Bench dataset, MM2019 (CONFERENCE), ORAL PRESENTER , 05/12/2019 to 08/12/2019
  • Microsecond molecular dynamics simulations of the active and inactive-state CB1 cannabinoid receptor following cross-docking: Agonist/antagonist discrimination in virtual screening., 2nd International Symposium on Bioinformatics (Symposium), ORAL PRESENTER , 20/12/2018 to 21/12/2018
  • Evaluating the Performance of MM/PBSA for Binding Affinity Prediction Using G Protein-Coupled Receptor Crystal Structures, International Conference on Drug Discovery and Translational Medicine 2018 (CONFERENCE), POSTER PRESENTER , 04/12/2018 to 05/12/2018
  • Evaluating the ability of unbiased molecular dynamics simulations to refine homology models of GPCRs: A case study using the adenosine A2A receptor, The 2nd International Conference On Pharmacy Education and Research Network of ASEAN (ASEAN PharmNET 2017) (CONFERENCE), POSTER PRESENTER , 21/11/2017 to 22/11/2017
  • An Assessment of G Protein-Coupled Receptor Homology Models Constructed from Templates of Various Transmembrane Sequence Identities, 13th MPS Scientific Conference (CONFERENCE), ORAL PRESENTER , 04/11/2017 to 05/11/2017