Senior Lecturer II
- School of Biosciences
Faculty of Health & Medical Sciences - sauhar.lee@taylors.edu.my
Dr Lee Sau Har
Academic Qualification
- Doctor of Philosophy, UNIVERSITI MALAYA, Malaysia
- Bachelor of Science (Biomedical Science), UNIVERSITI TUNKU ABDUL RAHMAN, Malaysia
Professional Qualification
No records found
Areas of Expertise
- Biological Sciences, Advancement Of Biological Science Knowledge, Cancer stem cell biology
- Biological Sciences, Advancement Of Biological Science Knowledge, Cancer Biology and Therapeutics
- Medical And Health Sciences, Medical Microbiology, Virology
- Medical And Health Sciences, Complimentary/Alternative Medicine, Traditional Medicine And Natural Products
Research Interest
- Reprogramming of mesenchymal stem cells for regenerative medicine purpose
- Elucidation of regulatory pathways of cancer stem cells
- Discovery of potential compounds against cancer and cancer stem cells
Publications
2024
- Association of microRNA-21 expression with breast cancer subtypes and its potential as an early biomarker (ISI-Indexed), Pathology - Research and Practice - Article in Journals
- miR-21 Expression and its Correlation with Demographics, Subtypes, and Tumour Suppressor Genes; PTEN and PDCD4 in Breast Cancer Tissues in Malaysia (ISI-Indexed), Eurasian Journal of Medicine and Oncology - Article in Journals
- Short Fragmented Peptides from Pardachirus Marmoratus Exhibit Stronger Anticancer Activities in In Silico Residue Replacement and Analyses, Current Drug Discovery Technologies - Article in Journals
2023
- Chemotherapy: how to reduce its adverse effects while maintaining the potency? (ISI-Indexed), Medical Oncology - Article in Journals
- miRNAs overexpression and their role in breast cancer: Implications for cancer therapeutics (ISI-Indexed), Current Drug Targets - Article in Journals
- The Therapeutic Anticancer Potential of Marine Derived Bioactive Peptides: A Highlight on Pardaxin (ISI-Indexed), International Journal of Peptide Research and Therapeutics - Article in Journals
2022
- Therapeutic targeting of overexpressed miRNAs in cancer progression (ISI-Indexed), CURRENT DRUG TARGETS - Article in Journals
- In silico Prediction and Physicochemical Analysis of Mutant Anticancer Short-length Pardaxin 6 Peptide Fragments Derived from Pardachirus Marmoratus (SCOPUS-Indexed) - Article in Proceeding
- Synthesis of PEGylated Liposome Co-loaded with Doxorubicin Hydrochloride and Tumour Suppressor miR-145 Mimics for Its Anti proliferative Effect Against Triple Negative Breast Cancer In vitro (SCOPUS-Indexed) - Article in Proceeding
- Association of High-risk Human Papillomavirus Titer and Pathogenic Co-infections with Cervical Tissue Cytopathology (ISI-Indexed), Eurasian Journal of Medicine and Oncology - Article in Journals
- Association of CYP24A1 with survival and drug resistance in clinical cancer patients: a meta-analysis (ISI-Indexed), BMC CANCER - Article in Journals
2021
- 5-Azacytidine pretreatment confers transient upregulation of proliferation and stemness in human mesenchymal stem cells (ISI-Indexed), Cells & Development - Article in Journals
- Breast cancer awareness and knowledge assessment among men and women in Malaysia (SCOPUS-Indexed), Journal of Public Health - Article in Journals
- Cationicity and Hydrophobicity Enhance the Cytotoxic Potency of Phoratoxin C Anticancer Peptide Analogues against Triple Negative Breast Cancer Cells (SCOPUS-Indexed), Current Bioactive Compounds - Article in Journals
- Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis (ISI-Indexed), PLoS One - Article in Journals
- Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine (ISI-Indexed), Stem Cells International - Article in Journals
2020
- Miltefosine suppression of Pten null T-ALL leukemia via -catenin degradation through inhibition of pT308-Akt and TGF 1/Smad3 (ISI-Indexed), Biochemical and Biophysical Research Communications - Article in Journals
- Regulatory Role of Quiescence in the Biological Function of Cancer Stem Cells (ISI-Indexed), Stem Cell Reviews and Reports - Article in Journals
- The potential of mesenchymal stromal cell as therapy in neonatal diseases (ISI-Indexed), Frontier in Pediatric - Article in Journals
- Establishing metastatic patient-derived xenograft model for colorectal cancer (ISI-Indexed), Japanese Journal of Clinical Oncology - Article in Journals
- Dietary Phytochemicals on Elimination of Cancer Stem Cells through Targeting its Quiescence and Survival Mechanisms (SCOPUS-Indexed), Journal of Health and Translational Medicine (JUMMEC) - Article in Journals
2019
- The Potential Use of Anticancer Peptides (ACPs) in the Treatment of Hepatocellular Carcinoma (ISI-Indexed), Current Cancer Drug Targets - Article in Journals
- Evaluating Antiproliferative Activities of Novel Hybridized Peptides against Hepatocellular Carcinoma Cells (HepG2) (SCOPUS-Indexed) - Article in Proceeding
- Novel Hybridized Peptides, NDs exhibited Antiproliferative Activity against Lung Adenocarcinoma (A549) Cells (SCOPUS-Indexed) - Article in Proceeding
2018
- Loss of Transfected Human Brain Micro-vascular Endothelial Cell Integrity during Herpes Simplex Virus Infection (ISI-Indexed), Intervirology - Article in Journals
- Evaluating Antiproliferative Activities of Hybridized Peptides against Hepatocellular Carcinoma Cells (HepG2) - Article in Proceeding
- Antiproliferative Effects of NDC2 and Its Analogues Against Human Hepatocellular Carcinoma (HepG2) Cell Line (ISI-Indexed) - Article in Proceeding
2017
- Japanese encephalitis virus disrupts blood-brain barrier and modulates apoptosis proteins in THBMEC cells (ISI-Indexed), VIRUS RESEARCH - Article in Journals
- NOTCH1 Signaling Regulates Self-renewal and Platinum Chemoresistance of Rare CD166+CD49fhiCD104- Cancer Stem Cells in Human Non-small-cell Lung Cancer (ISI-Indexed), CANCER RESEARCH - Article in Journals
2016
- Suppression of ERK1/2 and Hypoxia Pathways by Four Phyllanthus Species to Inhibit Metastasis of Human Breast Cancer Cell (MCF-7) (ISI-Indexed), JOURNAL OF FOOD AND DRUG ANALYSIS - Article in Journals
- Immune responses to influenza virus and its correlation to age and inherited factors (ISI-Indexed), FRONTIERS IN MICROBIOLOGY - Article in Journals
2014
- Phyllanthus sp: a local plant with multiple medicinal properties, JUMMEC - Article in Journals
2013
- Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2 (ISI-Indexed), BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE - Article in Journals
- Inhibition of Raf-MEK-ERK and Hypoxia pathways by Phyllanthus Prevents Metastasis in Human Lung (A549) Cancer Cell Line (ISI-Indexed), BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE - Article in Journals
2011
- Antimetastatic Effects of Phyllanthus on Human Lung (A549) and Breast (MCF-7) Cancer Cell Lines (ISI-Indexed), PLOS ONE - Article in Journals
Research
- A comparison of specificity and efficacy between the Atila Biosystem and Roche Cobas HPV detection tests for the detection of high-risk HPV with the clinical correlation and impact of viral titre and presence of other pathogenic co-infections against histopathological cervical tissue changes, Project Leader, 2021 to 2024, Private
- Elucidating the molecular target and the role of choline-geranic acid (CAGE) deep eutectic solvent in transdermal insulin delivery, Co-researcher, 2020 to 2023, National
- Investigating anticancer activity of anti-MIRNA 21, MIR-145 mimics and Doxorubicin Cocktail packaged in nanoparticles conjugated with A6 Tumour-homing peptide for targeted inhibition of triple-negative breast cancer , Project Leader, 2020 to 2024, National
- A self-cleavage Intein fusion tag for the recombinant expression of intact Antimicrobial Peptides in Escherichia coli for peptide-based drug biosynthesis, Co-researcher, 2019 to 2021, National
- Investigating an Association between Anticancer Peptides (ACPs) Cationicity with Selective Cytotoxicity Against an Aggressive Triple Negative Breast Cancer Cell Line , Project Leader, 2018 to 2020, Taylor's University
- Investigating the Role of Autophagy in Breast Cancer Cells Treated with Doxorubicin and Proteasome Inhibitor: Proof of Concept with Autophagy Inhibitor , Co-researcher, 2018 to 2020, Taylor's University
- Molecular Regulation of Lung Cancer Stem Cells, Project Leader, 2014, International
- Molecular Regulation of Lung Cancer Stem Cells , Project Leader, 2014 to 2015, Private
- Molecular Regulation of Lung Cancer Stem Cells , Project Leader, 2014 to 2015, International
- Anticancer properties of Phyllanthus spp: Mechanism of action and evaluation as potential antitumor agent, Co-researcher, 2011 to 2012, Private
Awards and Stewardship
- Silver Award, International University Carnival on E-Learning (IUCEL 2023), Education, Universiti Malaysia Pahang Al-Sultan Abdullah, Creativity , 2023
- Second Prize Poster Presentation Winner, Conference, Malaysian Association for Cancer Research (MACR), Best Poster Award , 2022
- Silver Award for Best Presentation in 4th International Conference on Medical Education Informatics (MEI 2021), Competition, University of Nottingham, Nottingham, UK, Best Presentation , 2021
- Silver Award for INVENTION, INNOVATION & DESIGN ON E-LEARNING (IIDEL) Competition from International University Carnival on E-Learning (IUCEL) 2021, Competition, Universiti Malaysia Sarawak (UNIMAS), Competition, Universiti Malaysia Sarawak (UNIMAS), Creativity , 2021
- Silver Award for INVENTION, INNOVATION & DESIGN ON E-LEARNING (IIDEL) Competition from International University Carnival on E-Learning (IUCEL) 2019, Competition, Universiti Malaysia Sarawak (UNIMAS), Creativity , 2019
- Center for Life Sciences Postdoctoral Fellowship, Education, Tsinghua University, Beijing, Fellowship , 2014
- Nobel Laureate Meeting Travel Award, Special, University Malaya Medical Centre (UMMC) (Pusat Perubatan Universiti Malaya)(PPUM), Travel Award , 2010
- ISCOMS 2010 Travel Award, Conference, University Medical Central, Rotterdam, Netherlands, Travel Award , 2010
- Best Session Oral Presenter, Conference, University Medical Central, Rotterdam, Netherlands, Best Oral , 2010
- National Science Fellowship, Education, Ministry of Higher Education, Fellowship , 2009
Paper Presented
- Optimising Dox-HCl-loaded PEGylated Liposome at Different Lipid Weight Ratios: Investigation of the Short-Term Stability and Drug release Efficiency, 13th Malaysia Symposium of Biomedical Science 2023 (Symposium), POSTER PRESENTER , 02/06/2023 to 03/06/2023
- Evaluation of in-vitro Anti-Proliferative Activities of Hybrid Peptides against Hepatocellular Carcinoma (HepG2) cells, YSN-ASM International Scientific Virtual Conference 2021 (CONFERENCE), POSTER PRESENTER , 29/03/2021 to 01/04/2021
- Novel Hybridized Peptides Possess Apoptotic Activities on Human Hepatocellular Carcinoma Cells (HepG2) via Intrinsic Pathway of Apoptosis, ASEAN Emerging Researchers Conference 2019 (CONFERENCE), POSTER PRESENTER , 09/12/2019 to 10/12/2019
- Novel Hybridized Peptides, NDs exhibited Antiproliferative Activity against Lung Adenocarcinoma (A549) Cells, International Health & Medical Sciences Conference (CONFERENCE), POSTER PRESENTER , 08/03/2019 to 09/03/2019
- Evaluating Antiproliferative Activities of Novel Hybridized Peptides against Hepatocellular Carcinoma Cells (HepG2), International Health & Medical Sciences Conference (CONFERENCE), POSTER PRESENTER , 08/03/2019 to 09/03/2019
- Antiproliferative Effects of NDC2 and Its Analogues Against Human Hepatocellular Carcinoma (HepG2) Cell Line, TYAN-YSN International Thematic Workshop (WORKSHOP), POSTER PRESENTER , 30/10/2018 to 01/11/2018
- Evaluating Antiproliferative Activities of Hybridized Peptides against Hepatocellular Carcinoma Cells (HepG2), Stem Cell and Cancer Symposium 2018 (Symposium), ORAL PRESENTER , 17/10/2018 to 18/10/2018
- Antiproliferative Effects of NDC2 and Its Analogues Against Human Hepatocellular Carcinoma (HepG2) Cell Line, International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) (CONFERENCE), ORAL PRESENTER , 03/12/2018 to 05/12/2018
- Effects of Potential of Malaysian Medicinal Plant (Phyllanthus) Against Dengue Virus Type 2 (DENV2), 9th Asia-Pacific Congress Medical Virology (APCMV) (CONGRESS), POSTER PRESENTER , 06/06/2012 to 08/06/2012
- Induction of Apoptosis without cell cycle arrest in A549 and MC F-7 cell lines treated with Phyllanthus spp. extracts, The 17th International Student Congress of Medical Sciences (ISCOMS) (CONFERENCE), ORAL PRESENTER , 08/06/2010 to 11/06/2010