Associate Professor
- School of Biosciences
Faculty of Health & Medical Sciences - siauhui.mah@taylors.edu.my
Associate Professor Dr Mah Siau Hui
Academic Qualification
- Doctor of Philosophy in Natural Products Chemistry, UNIVERSITY PUTRA MALAYSIA, Malaysia
- Bachelor of Science (Hons) in Petroleum Chemistry, UNIVERSITY PUTRA MALASYSIA, Malaysia
Professional Qualification
- PGCHeTL, TAYLOR'S UNIVERSITY, Malaysia
Areas of Expertise
- Medical And Health Sciences, Pharmaceutical Chemistry, Medicinal Chemistry
- Chemical Sciences, Organic Chemistry, Natural Products Chemistry
Research Interest
- Structure-Activity Relationship: Design and synthesis of biologically active compounds
- Isolation and structural elucidation of secondary metabolites from natural products
- Oil palm research: Palm-pressed fibre oil, oil palm biomass
Publications
2024
- Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents (ISI-Indexed), Phytotherapy Research - Article in Journals
- In vivo Retinoid Metabolic and Visual Cycle Pathways Assessment of Carotenoid-Rich Refined Red Palm-Pressed Mesocarp Olein (ISI-Indexed), Journal of Functional Foods - Article in Journals
- Topical Nanoemulsion Hydrogel Formulated from Supercritical Fluid Extracted Palm-Pressed Fiber Oil and Virgin Coconut Oil with Antioxidant and Antibacterial Effects (ISI-Indexed), Journal of Oleo Science - Article in Journals
2023
- Synthesis of Benzylated Amine-Substituted Xanthone Derivatives and Their Antioxidant and Anti-Inflammatory Activities (ISI-Indexed), Archiv der Pharmazie - Article in Journals
- Versatile Applications of Brewer's Spent Grain: Solid-State Fermentation and Nutritional Added-Value (ISI-Indexed), Applied Biochemistry and Biotechnology - Article in Journals
- Essential Oils as Potential Skin Antiinflammatory Agent and Their Mechanisms of Action - Book Chapter
- Synthesis of 1-Hydroxy-3-O-Substituted Xanthone Derivatives and Their Structure-Activity Relationship on Acetylcholinesterase Inhibitory Effect (ISI-Indexed), Natural Product Research - Article in Journals
- Kojic Acid and Kojic Acid Ester: Review on Nanotechnology-based Approach for Enhancing the Delivery Efficacy (SCOPUS-Indexed), Recent Advances In Drug Delivery and Formulation - Article in Journals
2022
- Physicochemical and functional properties of Flavourzyme-extracted protein hydrolysate from oil palm leaves (ISI-Indexed), Biomass Conversion and Biorefinery - Article in Journals
- Protective Effects of Alternanthera sessilis Ethanolic Extract Against TNF- or H2O2-induced Endothelial Activation in Human Aortic Endothelial Cells (ISI-Indexed), Evidence-Based Complementary and Alternative Medicine - Article in Journals
- Retinoids as Anti-cancer Agents and Their Mechanisms of Action (ISI-Indexed), American Journal of Cancer Research - Article in Journals
- Physicochemical and Functional Properties of Alcalase-Extracted Protein Hydrolysate from Oil Palm Leaves (ISI-Indexed), Journal of the Science of Food and Agriculture - Article in Journals
- Half-Maximal Inhibitory Concentration Determination of Acetylcholinesterase Enzyme by A Series of Synthetic Compounds for Alzheimer s Disease (SCOPUS-Indexed), International Journal of Public Health Science - Article in Journals
2021
- Editorial: Targeting human skin diseases with natural products: exploring potential mechanisms and regulatory pathways (ISI-Indexed), Frontiers in Pharmacology - Article in Journals
- A Review on Xanthones Derivatives with Anti-inflammatory Effects and Their Structure-Activity Relationship - Book Chapter
- New 3-O-Substituted Xanthone Derivatives as Promising Acetylcholinesterase Inhibitors (ISI-Indexed), Journal of Enzyme Inhibition and Medicinal Chemistry - Article in Journals
- Xanthone : Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment (ISI-Indexed), Mini-Reviews in Medicinal Chemistry - Article in Journals
- In vivo Toxicity Assessment of Refined Red Palm-pressed Mesocarp Olein in Sprague-Dawley Rat (ISI-Indexed), Journal of Oleo Science - Article in Journals
2020
- Anti-proliferative Effects of a Coumarin Benjaminin on Four Human Cancer Cell Lines, Pharmaceutical Sciences & Research - Article in Journals
- Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action And Potential Application (ISI-Indexed), Frontiers in Pharmacology - Article in Journals
- Hybrid Drying of Murraya Koenigii Leaves: Antidiabetic and Anti-ageing Activities (ISI-Indexed), SN Applied Sciences - Article in Journals
- Extraction Methods of Virgin Coconut Oil and Palm-pressed Mesocarp Oil and their Phytonutrients, eFood - Article in Journals
- Oxidative Stability and Physicochemical Properties of Palm Olein (ISI-Indexed), Journal of Oil Palm Research - Article in Journals
2019
- Crystal correlation of heterocyclic imidazo[1,2-a]pyridine analogues and their anticholinesterase potential evaluation (ISI-Indexed), Scientific Reports - Article in Journals
- Development of choline-based deep eutectic solvents for efficient concentrating of hemicelluloses in oil palm empty fruit bunches (ISI-Indexed), Korean Journal of Chemical Engineering - Article in Journals
- Comparative studies of selected Calophyllum plants for their anti-inflammatory properties (ISI-Indexed), Pharmacognosy Magazine - Article in Journals
- Palm-Pressed Mesocarp Fibre Oil as an Alternative Carrier Oil in Emulsion (ISI-Indexed), Journal of Oleo Science - Article in Journals
- Cytotoxic Xanthones Isolated from Calophyllum depressinervosum and Calophyllum buxifolium with Antioxidant and Cytotoxic Activities (ISI-Indexed), Food and Chemical Toxicology - Article in Journals
2018
- Radical scavenging potency of 2-(benzofuran-2-yl)-2-oxoethyl 3-(methyl/amino)benzoate: synthesis, crystal structure and Hirshfeld surface analysis (ISI-Indexed), Zeitschrift f r Kristallographie - Crystalline Materials - Article in Journals
- Effects of palm olein-olive oil blends on fat deposition in diet-induced obese mice (ISI-Indexed), Journal of Food and Nutrition Research - Article in Journals
- Phytochemicals from Calophyllum depressinervosum (ISI-Indexed), Asian Journal of Chemistry - Article in Journals
- Impact of storage conditions on the thermal and photo-stability of predominant phenolic constituents and antioxidant activity of dried Piper betle s extracts (ISI-Indexed), Molecules - Article in Journals
- Engaging Assessment Tools for the Twenty-First Century Students - Book Chapter
2017
- Evaluation of nitric oxide inhibition effect in LPS-stimulated RAW 264.7 macrophages by phytochemical constituents from Mesua beccariana, Mesua congestiflora, and Mesua ferrea (ISI-Indexed), Medicinal Chemistry Research - Article in Journals
- Isolation and structural modifications of ananixanthone from Calophyllum teysmannii and their cytotoxic activities (ISI-Indexed), Natural Products Research - Article in Journals
- Recovery and Utilization of Palm Oil Mill Effluent Source as Value-Added Food Products (ISI-Indexed), Journal of Oleo Science - Article in Journals
- Anti-inflammatory, anti-cholinergic and cytotoxic effects of Sida rhombifolia (ISI-Indexed), Pharmaceutical biology - Article in Journals
- Effect of Solvents on Phytochemical Concentrations and Antioxidant Activity of Garcinia benthamiana Stem Bark Extracts (SCOPUS-Indexed), Journal of Herbs, Spices and Medicinal Plants - Article in Journals
2016
- Structure-activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity (ISI-Indexed), Medicinal Chemistry Research - Article in Journals
- Determination of borneol and other chemical compounds of essential oil of Dryobalanops aromatica exudate from Malaysia (ISI-Indexed), Tropical Journal of Pharmaceutical Research - Article in Journals
- A new benzophenone from Garcinia benthamiana (ISI-Indexed), Records of Natural Products - Article in Journals
- Porcine Pancreatic Lipase Inhibitory Agent Isolated from Medicinal Herb and Inhibition Kinetics of Extracts from Eleusine indica (L.) Gaertner (ISI-Indexed), JOURNAL OF PHARMACEUTICS - Article in Journals
2015
- Synthesis and crystallographic insight into the structural aspects of some novel adamantane-based ester derivatives (ISI-Indexed), Molecules - Article in Journals
- A new coumarin from stem bark of Mesua hexapetala (ISI-Indexed), Natural Product Research - Article in Journals
- Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships (ISI-Indexed), Natural Product Research - Article in Journals
- Cytotoxic xanthones isolated from the stem bark of malaysian bintangor trees, Calophyllum spp. (ISI-Indexed), PLANTA MEDICA - Article in Journals
- Antiproliferative Xanthone Derivatives from Calophyllum inophyllum and Calophyllum soulattri (ISI-Indexed), Pakistan Journal of Pharmaceutical Sciences - Article in Journals
2014
- Calophyllum inophyllum and Calophyllum soulattri source of antiproliferative xanthones and their structure-activity relationships (ISI-Indexed), Natural Product Research - Article in Journals
- Antiproliferative properties of xanthones from Calophyllum inophyllum and Calophyllum soulattri towards human cancer cell lines (ISI-Indexed), PLANTA MEDICA - Article in Journals
2013
- New Xanthone and Coumarin Derivatives from Chemical Constituents of Mesua beccariana (ISI-Indexed), Research Journal of Chemistry and Environment - Article in Journals
- Chemical Constituents and New Xanthone Derivatives from Mesua ferrea and Mesua congestiflora (ISI-Indexed), Asian Journal of Chemistry - Article in Journals
- In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activities of Mesua beccariana (Baill.) Kosterm., Mesua ferrea Linn., and Mesua congestiflora Extracts (ISI-Indexed), BioMed Research International - Article in Journals
- Chemistry and Cytotoxic Activity of Essential Oil from the Stem Bark of Calophyllum soulattri (ISI-Indexed), Asian Journal of Chemistry - Article in Journals
- Cytotoxicity and structure-activity relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines (ISI-Indexed), Molecules - Article in Journals
2012
- A New Furanoxanthone from Root Bark of Mesua ferrea (ISI-Indexed), Letters in Organic Chemistry - Article in Journals
- Phylattrin, A New Cytotoxic Xanthone from Calophyllum soulattri (ISI-Indexed), Molecules - Article in Journals
- Mesua beccariana (Clusiaceae), A Source of Potential Anti-Cancer Lead Compounds in Drug Discovery (ISI-Indexed), Molecules - Article in Journals
- A New Benzophenone from Mesua congestiflora, an Inhibitor Against Human B Lymphocyte Cancer Cell Line (ISI-Indexed), Phytochemistry Letters - Article in Journals
- rac-[3-Hydroxy-6,9-dimethyl-6-(4-methylpent-3-en-1-yl)-6a,7,8,9,10,10a-hexahydro-6H-1,9-epoxybenzo[c]-chromen-4-yl](phenyl)methanone (ISI-Indexed), Acta Crystallographica Section E - Article in Journals
2011
- A New Pyranoxanthone from Calophyllum soulattri (ISI-Indexed), Molecules - Article in Journals
- A New Pyranoxanthone from the Stem Bark of Calophyllum inophyllum (ISI-Indexed), Letters in Organic Chemistry - Article in Journals
- Soulamarin, A New Coumarin from Stem Bark of Calophyllum soulattri (ISI-Indexed), Molecules - Article in Journals
- A New Furanoxanthone from the Stem Bark of Calophyllum inophyllum (ISI-Indexed), Journal of Asian Natural Products Research - Article in Journals
- Caloxanthone C: A Pyranoxanthone from the Stem Bark of Calophyllum soulattri (ISI-Indexed), Acta Crystallographica Section E - Article in Journals
2010
- Two New Pyranoxanthones from Mesua beccariana (Guttiferae) (ISI-Indexed), Molecules - Article in Journals
Research
- Metadynamics-directed modelling, synthesis, and in vitro evaluation of high affinity quercetin analogues targeting calcineurin, Co-researcher, 2023 to 2025, National
- Repurposing Biomass Waste: Nanocomposite Hydrogels from Oil Palm Mesocarp Fibers for Accelerated Wound Healing , Co-researcher, 2023 to 2025, Taylor's University
- Mechanism of Solute-Solvent Interaction and Extraction Kinetics of Carnosic Acid, Carnosol and Rosmarinic Acid Prevailing In Tunable Hydrophobic-Hydrophilic Deep Eutectic Solvent System, Co-researcher, 2022 to 2025, National
- Evaluation of effect of a new xanthone derivative, 3- phenylbutylxanthone, on TNF- -induced endothelial activation, Co-researcher, 2022 to 2023, Private
- Mechanism of Solute-Solvent Interaction and Extraction Kinetics of Carnosic Acid, Carnosol and Rosmarinic Acid Prevailing In Tunable Hydrophobic-Hydrophilic Deep Eutectic Solvent System, Co-researcher, 2022 to 2025, National
- Unravelling black soldier fly larvae as meat alternatives: Protein quality and modification through physical and chemical processing methods, Co-researcher, 2021 to 2024, National
- Effect of the palm press fibre oil toward Vitamin A defiency rats in terms of visualization, atherosclerosis and toxicological studies, Project Leader, 2020 to 2022, Private
- Evaluation of effects of Alternanthera sessilis ethanol extract on TNF-a -induced oxidative stress and endothelial dysfunction on human aortic endothelial cells, Co-researcher, 2020 to 2022, National
- Curcumin analogues with N-methyl 4-piperidone linker suppress immune functions and MyD88-dependent NF-kB/MAPKs/ PI3-Akt signaling pathways in LPS-primed macrophages, Project Leader, 2020 to 2024, National
- Synthesis, Molecular Docking and Structure-Activity Relationship Analysis of 3-Hydroxyxanthone-based Derivatives as Novel Cholinesterase and Cyclooxygenase Inhibitors, Project Leader, 2019 to 2022, National
Awards and Stewardship
- Best Brochure, Exhibition/Invention, Universiti Teknologi Malaysia (UTM), Best Brochure , 2023
- Bronze Award in Innovation Project, Exhibition/Invention, Universiti Teknologi Malaysia (UTM), Bronze Award , 2023
- Select Lecture Award, Conference, Japan Oil Chemists' Society, Select Lecture , 2022
- Silver Award in Innovation Product Presentation Category Waste Treatment/Biotechnology/Green Technology, Competition, Universiti Teknologi Malaysia (UTM), Innovation Product , 2022
- Early Career Chemist Travel Grant Award for International Congress of Pacific Basin Societies , Conference, American Chemical Society (ACS), Travel Grant , 2021
- The Virtual International e-Content Development Competition 2021, Education, Kementerian Pendidikan Malaysia, Gold Award , 2021
- International University Carnival on e-Learning 2021, Education, Kementerian Pendidikan Malaysia, Silver Medal , 2021
- Pharmaceutical Sciences and Research Travel Grant Award-The Asian Federation for Pharmaceutical Sciences Conference (AFPS 2019), Conference, Universitas Indonesia, Travel Grant , 2019
- President's Award 2017, Education, Taylor's University, Excellence in Research and Innovation , 2017
- Early Career Chemist Travel Grant Award-International Congress of Pacific Basin Societies (Pacifichem 2015), Conference, American Chemical Society (ACS), Travel Grant , 2015
Paper Presented
- Xanthones with Acetylcholinesterase Inhibitory Activities, Fifth International Symposium on Phytochemicals in Medicine and Food (5-ISPMF) (CONFERENCE), INVITED SPEAKER , 25/08/2021 to 30/08/2021
- Festival Training Institute, Festival Training Institute (WORKSHOP), INVITED SEMINAR , 28/02/2017 to 01/03/2017
- Monitoring and Sustaining Success, Outreach Training Programme (WORKSHOP), INVITED SEMINAR , 21/07/2020 to 21/07/2020
- A Journal Editor's Perspective - Tips for Researchers, A Journal Editor's Perspective - Tips for Researchers (SEMINAR), INVITED SEMINAR , 24/09/2020 to 24/09/2020
- 3-O-Substituted Xanthone Derivatives as Potential Cholinesterase Inhibitors, Fourth International Symposium on Phytochemicals in Medicine and Food (4-ISPMF) (CONFERENCE), INVITED SPEAKER , 30/11/2020 to 05/12/2020
- Xanthones Isolated from Calophyllum depressinervosum and Calophyllum buxifolium with Cytotoxic Effects Towards Human Cancer Cells, 1st International Conference on Natural Toxicology and Pharmacology (1-ICNTP) (CONFERENCE), INVITED SPEAKER , 07/08/2019 to 11/08/2019
- Cytotoxic Effects of Xanthones Isolated from Calophyllum Plants towards SNU-1 and LS174T Human Cancer Cells, Third International Symposium on Phytochemicals in Medicine and Food (3-ISPMF) (CONFERENCE), INVITED SPEAKER , 25/08/2018 to 30/08/2018
- Potential Natural Food Sources from Palm Oil Mill, The Asian Conference on Oleo Science 2017 (ACOS 2017 (CONFERENCE), INVITED SPEAKER , 11/09/2017 to 13/09/2017