Associate Professor
- School of Biosciences
Faculty of Health & Medical Sciences - chungyeng.looi@taylors.edu.my
Associate Professor Dr Looi Chung Yeng
Academic Qualification
- PhD in Medical Sciences, TOHOKU UNIVERSITY JAPAN, Japan
- Master of Science (Medical Sciences), TOHOKU UNIVERSITY JAPAN, Japan
- Bachelor of Science (Hons) Biomedical Sciences, UNIVERSITY PUTRA MALAYSIA, Malaysia
Professional Qualification
No records found
Areas of Expertise
- Medical And Health Sciences, Pharmacology, Molecular Pharmacology
Research Interest
- Elucidating drug targets and mechanism of action by using cell-line and animal models Evaluation of natural/synthetic compounds for anti-cancer and anti-inflammatory activities Understanding carcinogenesis and immunological disorders using molecular and biochemical analyses Explore novel interventions in cancer and immunological disorders
Publications
2023
- Recent Development of Nanomaterials for Transdermal Drug Delivery (ISI-Indexed), Biomedicines - Article in Journals
- Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis (ISI-Indexed), Cellular Immunology - Article in Journals
- Recent Advancement of Medical Patch for Transdermal Drug Delivery (ISI-Indexed), Medicina-Lithuania - Article in Journals
- Current development of chemical penetration enhancers for transdermal insulin delivery (ISI-Indexed), Biomedicines - Article in Journals
- A Systematic Review of Molecular Hydrogen Therapy in Cancer Management (ISI-Indexed), Asian Pacific Journal of Cancer Prevention - Article in Journals
2022
- Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses (ISI-Indexed), Int. J. Mol. Sci - Article in Journals
- A Comprehensive Review of the Evolution of Insulin Development and Its Delivery Method. (ISI-Indexed), Pharmaceutics - Article in Journals
- Characterization deep eutectic solvents for optimal transdermal drug delivery (SCOPUS-Indexed) - Article in Proceeding
- Redesigning Biomedical Science Practicum towards a New Frontier, International Journal of Information and Education Technology (SCOPUS-Indexed), International Journal of Information and Education Technology - Article in Journals
- Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis (ISI-Indexed), Cellular immunology - Article in Journals
2021
- The role of smoothened-dependent and-independent hedgehog signaling pathway in tumorigenesis (ISI-Indexed), Biomedicines - Article in Journals
- Podoplanin Drives Motility of Active Macrophage via Regulating Filamin C During Helicobacter pylori Infection (ISI-Indexed), Frontiers in Immunology - Article in Journals
- An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment (ISI-Indexed), Microorganisms - Article in Journals
- Non-toxic nature of chebulinic acid on biochemical, hematological and histopathological analysis in normal Sprague Dawley rats (ISI-Indexed), Toxicological Research - Article in Journals
- Defining the Role of GLI/Hedgehog Signaling in Chemoresistance: Implications in Therapeutic Approaches (ISI-Indexed), Cancers - Article in Journals
2020
- Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or Pulmonary Chlamydia Infections (ISI-Indexed), Microorganisms - Article in Journals
- Simulation of Deep Eutectic Solvents' Interaction with Membranes of Cancer Cells Using COSMO-RS (ISI-Indexed), J Phys Chem B . - Article in Journals
- Comparison of Isolation, Expansion and Cryopreservation Techniques to Produce Stem Cells from Human Exfoliated Deciduous teeth (SHED) with better Regenerative Potential. (ISI-Indexed), Curr Stem Cell Res Ther. - Article in Journals
2019
- Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication., Frontiers in Oncology - Article in Journals
- Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems. (ISI-Indexed), J Control Release - Article in Journals
- The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy. (ISI-Indexed), Front Microbiol. - Article in Journals
- The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. (ISI-Indexed), Cells - Article in Journals
- Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. (ISI-Indexed), PLoS One - Article in Journals
2018
- Phenylpropanoids isolated from Piper sarmentosum Roxb. induce apoptosis in breast cancer cells through reactive oxygen species and mitochondrial-dependent pathways (ISI-Indexed), Chemico-Biological Interactions - Article in Journals
- Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents (ISI-Indexed), Materials Science and Engineering: C - Article in Journals
- Laevifins A-G, clerodane diterpenoids from the Bark of Croton oblongus Burm.f. (ISI-Indexed), Phytochemistry - Article in Journals
- Transcriptomic and Genomic Approaches for Unravelling Candida albicans Biofilm Formation and Drug Resistance-An Update. (ISI-Indexed), Genes - Article in Journals
2017
- Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review. (ISI-Indexed), Current Drug Targets - Article in Journals
- MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma (ISI-Indexed), Oncotarget - Article in Journals
- Renal targeting potential of a polymeric drug carrier, poly-l-glutamic acid, in normal and diabetic rats (ISI-Indexed), International Journal of Nanomedicine - Article in Journals
- Multiple Players in the Mechanical Control of T Cell Quiescence - Book Chapter
- Corrigendum: Apoptotic effect of novel Schiff Based CdCl2(C14H21N3O2) complex is mediated via activation of the mitochondrial pathway in colon cancer cells. (ISI-Indexed), Scientific Reports - Article in Journals
2016
- Natural deep eutectic solvents: cytotoxic profile (ISI-Indexed), Springerplus - Article in Journals
- Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell (ISI-Indexed), Journal of Experimental and Clinical Cancer Research - Article in Journals
- An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer (ISI-Indexed), International Journal of Medical Sciences - Article in Journals
- Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line (ISI-Indexed), PLoS One - Article in Journals
- Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains (ISI-Indexed), Organic & Biomolecular Chemistry - Article in Journals
2015
- Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study (ISI-Indexed), Drug Des Devel Ther - Article in Journals
- Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo (ISI-Indexed), J Exp Clin Cancer Res - Article in Journals
- Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves beta-cell function in streptozotocin-nicotinamide induced diabetic rats (ISI-Indexed), Journal of Ethnopharmacology - Article in Journals
- In Vitro and In Vivo toxicity profiling of ammonium-based deep eutectic solvents (ISI-Indexed), Plos One - Article in Journals
- Apoptotic effect of novel Schiff based CdCl(2)(C(1)(4)H(2)(1)N(3)O(2)) complex is mediated via activation of the mitochondrial pathway in colon cancer cells (ISI-Indexed), Nature Scientific Reports - Article in Journals
2014
- Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-kappaB pathways (ISI-Indexed), Drug Des Devel Ther - Article in Journals
- Cytotoxic constituents from the rhizomes of Curcuma zedoaria (ISI-Indexed), Scientific World Journal - Article in Journals
- A Schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway (ISI-Indexed), Scientific World Journal - Article in Journals
- Synthesis, characterization, and anticancer activity of new quinazoline derivatives against MCF-7 cells (ISI-Indexed), Scientific World Journal - Article in Journals
- Subditine, a new monoterpenoid indole alkaloid from bark of Nauclea subdita (Korth.) Steud. induces apoptosis in human prostate cancer cells (ISI-Indexed), PLoS One - Article in Journals
2013
- Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode (ISI-Indexed), Bioorganic & Medicinal Chemistry Letters - Article in Journals
- Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds (ISI-Indexed), PLoS One - Article in Journals
2012
- Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-kappaB Inhibition (ISI-Indexed), Evid Based Complement Alternat Med - Article in Journals
- Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, beta-TC6 and its alleviating role in type 2 diabetic rats (ISI-Indexed), Journal of Ethnopharmacology - Article in Journals
- The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats (ISI-Indexed), Food and Chemical Toxicology - Article in Journals
Research
- Profiling human salivary biomarker(s) panel as a non-invasive detection method for myocardial infarction (MI), Project Leader, 2023 to 2025, Taylor's University
- Selective isolation method, characterization, and functionalization of nanocrystalline cellulose from oil palm frond fiber (OPFF) with antimicrobial activities, Co-researcher, 2021 to 2024, National
- Investigating anticancer activity of anti-MIRNA 21, MIR-145 mimics and Doxorubicin Cocktail packaged in nanoparticles conjugated with A6 Tumour-homing peptide for targeted inhibition of triple-negative breast cancer , Co-researcher, 2020 to 2024, National
- Elucidating the molecular target and the role of choline-geranic acid (CAGE) deep eutectic solvent in transdermal insulin delivery, Project Leader, 2020 to 2023, National
- Copper as target for colorectal cancer therapeutics: Anti-cancer effect of copper (II) complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin, Co-researcher, 2018 to 2019, Taylor's University
- The role of RUNX3 and E-cadherin underlying epithelial to mesenchymal (EMT)-associated cellular plasticity in gastric cancer, Project Leader, 2018 to 2019, Taylor's University
- Immunomodulatory and anti-inflammatory effects of Tualang and Kelulut honeys on activated microglial cells, Co-researcher, 2017 to 2019, Taylor's University
Awards and Stewardship
- International University Carnival on E-Learning (IUCEL) 2023, Competition, Universiti Malaysia Pahang Al-Sultan Abdullah, Bronze , 2023
- Silver award, Exhibition/Invention, Malaysian Invention and Design Society (MINDS), Collaborator , 2023
- Anugerah Khas Menteri Pengajian Tinggi: Rekabentuk Kurikulum Dan Penyampaian Inovatif (AKRI) 2022, Competition, Kementerian Pendidikan Malaysia, 2022 , Education, Ministry of Higher Education, Contributor , 2022
- Silver Medal in the poster competition for poster entitled Redesigning Biomedical Science Practicum Towards A New Frontier . 2021 edition of International University Carnival on E-Learning (IUCEL 2021): "Leading Innovation Towards Digitalized Community", 15 16 June 202, Education, Universiti Utara Malaysia (UUM), Contributor , 2021
- Silver Medal in the oral competition entitled Redesigning Biomedical Science Practicum Towards A New Frontier . MEI2021 4th International Conference on Medical Education Informatics, Competition, University of Nottingham, Nottingham, UK, Best Oral , 2021
Paper Presented
No records found