Senior Lecturer II
- School of Biosciences
Faculty of Health & Medical Sciences - 03-56295099
- yinsim.tor@taylors.edu.my
Dr Tor Yin Sim
Academic Qualification
- Doctor of Philosophy, UNIVERSITI PUTRA MALAYSIA, Malaysia
- Bachelor of Science (Biomedical Sciences), UNIVERSITI PUTRA MALAYSIA, Malaysia
Professional Qualification
No records found
Areas of Expertise
- Medical And Health Sciences, Clinical Medicine, Genetic epidemiology
- Medical And Health Sciences, Pharmacology, Molecular Pharmacology
Research Interest
No records found
Publications
2024
- Immunomodulatory gene polymorphisms in non-small cell lung carcinoma susceptibility and survival (ISI-Indexed), Heliyon - Article in Journals
2023
- Non-commercial Plant-based Edible Oil for Prevention and Treatment of Chronic Diseases - Book Chapter
2022
- Induction of Apoptosis and Autophagy by Ternary Copper Complex Towards Breast Cancer Cells (ISI-Indexed), ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY - Article in Journals
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Insulin Resistance in Type 2 Diabetes Mellitus Rats (ISI-Indexed), Pharmaceutics - Article in Journals
- Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells (ISI-Indexed), Cell biochemistry and function - Article in Journals
2021
- BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder (ISI-Indexed), J Mol Neurosci - Article in Journals
- Benchtop Isolation and Characterisation of Small Extracellular Vesicles from Human Mesenchymal Stem Cells (ISI-Indexed), Molecular Biotechnology - Article in Journals
- Ternary Copper (II) Complex Induced Apoptosis and Cell Cycle Arrest in Colorectal Cancer Cells (ISI-Indexed), Anti-Cancer Agents in Medicinal Chemistry - Article in Journals
- Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways (ISI-Indexed), INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS - Article in Journals
2020
- Mesenchymal stem cell therapy for sports injuries - from research to clinical practice. (ISI-Indexed), Sains Malaysiana - Article in Journals
- Predictors of recurrence of major depressive disorder (ISI-Indexed), PLoS One - Article in Journals
- BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder, Journal of Molecular Neuroscience - Article in Journals
2019
- Isolation of Cardamonin and Pinostrobin Chalcone from the Rhizomes of Boesenbergia rotunda (L.) Mansf. and their Cytotoxic Effects on H-29 and MDA-MB-231 Cancer Cell Lines (SCOPUS-Indexed), The Natural Products Journal - Article in Journals
- Induction of Cell Cycle Arrest and Apoptosis by Copper Complex Cu(SBCM)2 Towards Oestrogen-Receptor Positive MCF-7 Breast Cancer Cells. (ISI-Indexed), RSC Advances - Article in Journals
- Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients (ISI-Indexed), PLoS One - Article in Journals
- Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathway (SCOPUS-Indexed), Biotechnology Reports - Article in Journals
- Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian Subjects. (SCOPUS-Indexed), Neuroscience Research Notes - Article in Journals
2018
- Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell (ISI-Indexed), Biometals - Article in Journals
- Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice (ISI-Indexed), Nanomedicine - Article in Journals
- Anti-ulcer properties of kelulut honey against ethanol-induced gastric ulcer, Pertanika Journal of Science and Technology - Article in Journals
2016
- Endoplasmic reticulum stress-induced apoptotic pathway and mitochondrial dysregulation in HeLa cells treated with dichloromethane extract of Dillenia suffruticosa (ISI-Indexed), Pharmacognosy Magazine - Article in Journals
- Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice (ISI-Indexed), International Journal of Nanomedicine - Article in Journals
- Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231 (ISI-Indexed), BMC Complementary and Alternative Medicine - Article in Journals
- Chemopreventive properties and toxicity of kelulut honey in sprague dawley rats induced with azoxymethane (ISI-Indexed), Biomed Research International - Article in Journals
- Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells (ISI-Indexed), Journal of Ethnopharmacology - Article in Journals
2015
- Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice (ISI-Indexed), Asian Pacific Journal of Tropical Biomedicine - Article in Journals
- Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa, and its chemical profile. (ISI-Indexed), PLoS One - Article in Journals
- Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway (ISI-Indexed), Journal of Ethnopharmocology - Article in Journals
2014
- Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signaling pathways (ISI-Indexed), Bmc Complementary and Alternative Medicine - Article in Journals
2013
- Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis (ISI-Indexed), Molecules - Article in Journals
2012
- Chemopreventive potential of Annona muricata L. leaves on chemically-induced skin papillomagenesis in mice (ISI-Indexed), Asian Pacific Journal of Cancer Prevention - Article in Journals
Research
- Formulation, optimisation, and characterisation of tumor-targeted liposomes for targeted delivery of anticancer peptide D18.13 to breast cancer cells in vitro , Co-researcher, 2024 to 2025, Taylor's University
- Development of human umbilical cord-derived Mesenchymal Stem Cells (hUCB-MSC) and exosomes for the treatment of Diabetes mellitus type 2, Co-researcher, 2019 to 2022, Private
- Targeting Alpha-Mannosidase II with Novel Swainsonine Analogues: Potential Anticancer Candidates Acting On Glycosylation Pathways, Co-researcher, 2019 to 2022, National
- Interferon gamma in regulating Programmed Death-1 Ligand-1 (PD-L1): A prognostic marker in Malaysian non-small cell lung carcinoma (NSCLC), Project Leader, 2019 to 2023, National
- Investigating the Role of Autophagy in Breast Cancer Cells Treated with Doxorubicin and Proteasome Inhibitor: Proof of Concept with Autophagy Inhibitor , Co-researcher, 2018 to 2020, Taylor's University
- Copper as target for colorectal cancer therapeutics: Anti-cancer effect of copper (II) complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin, Project Leader, 2018 to 2019, Taylor's University
- The role of RUNX3 and E-cadherin underlying epithelial to mesenchymal (EMT)-associated cellular plasticity in gastric cancer, Co-researcher, 2018 to 2019, Taylor's University
Awards and Stewardship
- Best Paper Award (Third Prize)., Conference, University of Malaya (UM), Best Oral , 2017
- Best Poster Presentation Award, Conference, Universiti Putra Malaysia (UPM), Best Poster Award , 2014
Paper Presented
- Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa, 5th International Conference on Natural Products for Health and Beauty (NATPRO 5) (CONFERENCE), POSTER PRESENTER , 06/05/2014 to 08/05/2014
- Vitamin D receptor polymorphisms and risk of Major Depressive Disorder. , 29th World Congress of the International Association for Suicide Prevention (IASP) and The 21st Malaysian Conference on Psychological Medicine (MCMP) (CONFERENCE), ORAL PRESENTER , 18/07/2017 to 22/07/2017