• Senior Lecturer II

  • School of Biosciences
    Faculty of Health & Medical Sciences
  •    03-56295099
  •   yinsim.tor@taylors.edu.my


Dr Tor Yin Sim


Academic Qualification

  • Doctor of Philosophy, UNIVERSITI PUTRA MALAYSIA, Malaysia
  • Bachelor of Science (Biomedical Sciences), UNIVERSITI PUTRA MALAYSIA, Malaysia

Professional Qualification

No records found

Areas of Expertise

  • Medical And Health Sciences, Clinical Medicine, Genetic epidemiology
  • Medical And Health Sciences, Pharmacology, Molecular Pharmacology

Research Interest

No records found

Publications

2023
  • Non-commercial Plant-based Edible Oil for Prevention and Treatment of Chronic Diseases - Book Chapter
2022
  • Induction of Apoptosis and Autophagy by Ternary Copper Complex Towards Breast Cancer Cells (ISI-Indexed), ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY - Article in Journals
  • Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Insulin Resistance in Type 2 Diabetes Mellitus Rats (ISI-Indexed), Pharmaceutics - Article in Journals
  • Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells (ISI-Indexed), Cell biochemistry and function - Article in Journals
2021
  • BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder (ISI-Indexed), J Mol Neurosci - Article in Journals
  • Benchtop Isolation and Characterisation of Small Extracellular Vesicles from Human Mesenchymal Stem Cells (ISI-Indexed), Molecular Biotechnology - Article in Journals
  • Ternary Copper (II) Complex Induced Apoptosis and Cell Cycle Arrest in Colorectal Cancer Cells (ISI-Indexed), Anti-Cancer Agents in Medicinal Chemistry - Article in Journals
  • Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways (ISI-Indexed), INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS - Article in Journals
2020
  • Mesenchymal stem cell therapy for sports injuries - from research to clinical practice. (ISI-Indexed), Sains Malaysiana - Article in Journals
  • Predictors of recurrence of major depressive disorder (ISI-Indexed), PLoS One - Article in Journals
  • BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder, Journal of Molecular Neuroscience - Article in Journals
2019
  • Isolation of Cardamonin and Pinostrobin Chalcone from the Rhizomes of Boesenbergia rotunda (L.) Mansf. and their Cytotoxic Effects on H-29 and MDA-MB-231 Cancer Cell Lines (SCOPUS-Indexed), The Natural Products Journal - Article in Journals
  • Induction of Cell Cycle Arrest and Apoptosis by Copper Complex Cu(SBCM)2 Towards Oestrogen-Receptor Positive MCF-7 Breast Cancer Cells. (ISI-Indexed), RSC Advances - Article in Journals
  • Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients (ISI-Indexed), PLoS One - Article in Journals
  • Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathway (SCOPUS-Indexed), Biotechnology Reports - Article in Journals
  • Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian Subjects. (SCOPUS-Indexed), Neuroscience Research Notes - Article in Journals
2018
  • Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell (ISI-Indexed), Biometals - Article in Journals
  • Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity in 4T1 tumor-bearing mice (ISI-Indexed), Nanomedicine - Article in Journals
  • Anti-ulcer properties of kelulut honey against ethanol-induced gastric ulcer, Pertanika Journal of Science and Technology - Article in Journals
2016
  • Endoplasmic reticulum stress-induced apoptotic pathway and mitochondrial dysregulation in HeLa cells treated with dichloromethane extract of Dillenia suffruticosa (ISI-Indexed), Pharmacognosy Magazine - Article in Journals
  • Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice (ISI-Indexed), International Journal of Nanomedicine - Article in Journals
  • Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231 (ISI-Indexed), BMC Complementary and Alternative Medicine - Article in Journals
  • Chemopreventive properties and toxicity of kelulut honey in sprague dawley rats induced with azoxymethane (ISI-Indexed), Biomed Research International - Article in Journals
  • Dillenia suffruticosa dichloromethane root extract induced apoptosis towards MDA-MB-231 triple-negative breast cancer cells (ISI-Indexed), Journal of Ethnopharmacology - Article in Journals
2015
  • Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice (ISI-Indexed), Asian Pacific Journal of Tropical Biomedicine - Article in Journals
  • Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa, and its chemical profile. (ISI-Indexed), PLoS One - Article in Journals
  • Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway (ISI-Indexed), Journal of Ethnopharmocology - Article in Journals
2014
  • Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signaling pathways (ISI-Indexed), Bmc Complementary and Alternative Medicine - Article in Journals
2013
  • Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis (ISI-Indexed), Molecules - Article in Journals
2012
  • Chemopreventive potential of Annona muricata L. leaves on chemically-induced skin papillomagenesis in mice (ISI-Indexed), Asian Pacific Journal of Cancer Prevention - Article in Journals

Research

  • Development of human umbilical cord-derived Mesenchymal Stem Cells (hUCB-MSC) and exosomes for the treatment of Diabetes mellitus type 2,  Co-researcher2019 to 2022, Private
  • Targeting Alpha-Mannosidase II with Novel Swainsonine Analogues: Potential Anticancer Candidates Acting On Glycosylation Pathways,  Co-researcher2019 to 2022, National
  • Interferon gamma in regulating Programmed Death-1 Ligand-1 (PD-L1): A prognostic marker in Malaysian non-small cell lung carcinoma (NSCLC),  Project Leader2019 to 2023, National
  • The role of RUNX3 and E-cadherin underlying epithelial to mesenchymal (EMT)-associated cellular plasticity in gastric cancer,  Co-researcher2018 to 2019, Taylor's University
  • Investigating the Role of Autophagy in Breast Cancer Cells Treated with Doxorubicin and Proteasome Inhibitor: Proof of Concept with Autophagy Inhibitor ,  Co-researcher2018 to 2020, Taylor's University
  • Copper as target for colorectal cancer therapeutics: Anti-cancer effect of copper (II) complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin,  Project Leader2018 to 2019, Taylor's University

Awards and Stewardship

  • Best Paper Award (Third Prize)., Conference, University of Malaya (UM), Best Oral , 2017
  • Best Poster Presentation Award, Conference, Universiti Putra Malaysia (UPM), Best Poster Award , 2014

Paper Presented

  • Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa, 5th International Conference on Natural Products for Health and Beauty (NATPRO 5) (CONFERENCE), POSTER PRESENTER , 06/05/2014 to 08/05/2014
  • Vitamin D receptor polymorphisms and risk of Major Depressive Disorder. , 29th World Congress of the International Association for Suicide Prevention (IASP) and The 21st Malaysian Conference on Psychological Medicine (MCMP) (CONFERENCE), ORAL PRESENTER , 18/07/2017 to 22/07/2017