Curriculum Vitae


Associate Professor Dr Yap Wei Hsum

  • Senior Lecturer II, Faculty of Health & Medical Sciences, 17/05/2013 to present
  • Doctor of Philosophy (Science), UNIVERSITY TUNKU ABDUL RAHAMAN, Malaysia
  • Bachelor of Science (Hons) in Biotechnology, UNIVERSITI TUNKU ABDUL RAHMAN, Malaysia
  • Molecular Pharmacology
(Research Area)
  • Macrophage foam cells
  • Skin models
(Title of publication in APA style)
Book Chapter
  • YS Ong, KY Khaw, LTH Tan, PN Yew, KB Tan, WH Yap, SY Tang, LE Low, LH Lee, BH Goh (2021) An Overview of the Bioactivities of Gedunin. In: Pal D., Nayak A.K. (eds) Bioactive Natural Products for Pharmaceutical Applications. Advanced Structured Materials, vol 140. Springer, Cham.
  • Hassan, N., Sellappans, R., Yong Voon Chen, P., Yap, W. H., Ayub, E., Konstantinidis, S. T., Poussa, C., Wharrad, H. J., & Taylor, M. G. (2021). Participatory Approach in Reusable Learning Object (RLO) Development Using ASPIRE Framework: Taylor's University's Experience. In Nair, P., Keppell, M. J., Lim, C. L., Mari, T., & Hassan, N. (Ed.), Transforming Curriculum Through Teacher-Learner Partnerships (pp. 90-104). IGI Global. http://doi:10.4018/978-1-7998-6445-5.ch006
  • Neo, Y. P., & Yap, W. H. (2020). Teach Less, Learn More: A Paradigm Through Collaborative Learning in Science. In P. Kumar, M. Keppell, & C. Lim (Eds.), Preparing 21st Century Teachers for Teach Less, Learn More (TLLM) Pedagogies (pp. 10-29). Hershey, PA: IGI Global. doi:10.4018/978-1-7998-1435-1.ch002
  • Zee-Wei, L. and Wei-Hsum Yap (2020). Promoting Role Play Simulation Activities in Sciences-based Modules. In P. Kumar, M. Keppell, & C. Lim (Eds.), Preparing 21st Century Teachers for Teach Less, Learn More (TLLM) Pedagogies. (pp.125-141). Hershey, PA: IGI Global. DOI: 10.4018/978-1-7998-1435-1.ch008
  • Yap, W. H. (2018). Supporting Group Learning Using Collaborative Networked Platforms. In S. Tang, & C. Lim (Eds.), Preparing the Next Generation of Teachers for 21st Century Education (pp. 144-164). Hershey, PA: IGI Global. doi:10.4018/978-1-5225-4080-9.ch009
Article in Journals
  • Abbas, N., Tan, H.D., Gog, B.H., Yap, W.H., Tang, Y.Q. (2023). In-Silico Study of Anticancer and Antimicrobial Peptides Derived from Cycloviolacin O2 (CyO2). Biointerface Research in Applied Chemistry. (Accepted) (ISI-Indexed)
  • Low LE, Kong CK, Yap WH, Siva SP, Gan SH, Siew WS, Ming LC, Lai-Foenander AS, Chang SK, Lee WL, Wu Y, Khaw KY, Ong YS, Tey BT, Singh SK, Dua K, Chellappan DK, Goh BH. Hydroxychloroquine: Key therapeutic advances and emerging nanotechnological landscape for cancer mitigation. Chem Biol Interact. 386:110750 (ISI-Indexed)
  • Yap, W.H.; Goh, B.H. Editorial: Biofunctional Molecule Exploratory Research on Application in Food and Health. Molecules 2023, 28, 5089. (ISI-Indexed)
  • Vellasamy, D.M.; Lee, S.-J.; Goh, K.W.; Goh, B.-H.; Tang, Y.-Q.; Ming, L.C.; Yap, W.H. Targeting Immune Senescence in Atherosclerosis. Int. J. Mol. Sci. 2022, 23, 13059. (ISI-Indexed)
  • Tan, H.D., Leong, H.J.Y., Yap, W.H., Chia, A.Y.Y., Tang, Y-Q. (2023). Network Analysis in the Identification of Genes Conferring Metastatic Potential in Hepatocellular Carcinoma. Eurasian Journal of Medicine and Oncology. (Accepted) (ISI-Indexed)
  • Lim HM, Ng CJ, Wharrad H, Lee YK, Teo CH, Lee PY, et al. (2022) Knowledge transfer of eLearning objects: Lessons learned from an intercontinental capacity building project. PLoS ONE 17(9): e0274771. (ISI-Indexed)
  • Yap WH, Zhang J, Li M, Guo Y. Editorial: The genetics of human Mendelian skin disorders. Front Genet. 2022 Dec 1;13:1061724. doi: 10.3389/fgene.2022.1061724. PMID: 36531233; PMCID: PMC9752019. (ISI-Indexed)
  • Siew, W.S., Tang, Y.Q., Yap, W.H. (2022). Integrated Assessment of Macrophage Lipids Homeostasis Omics Data: Identification of Potential Genes and Pathways in Atherosclerosis. Progress in Drug Discovery & Biomedical Science. 5(1). (SCOPUS-Indexed)
  • Cho, W.Y.; Ng, J.F.; Yap, W.H.; Goh, B.H. Sophorolipids—Bio-Based Antimicrobial Formulating Agents for Applications in Food and Health. Molecules 2022, 27, 5556. (SCOPUS-Indexed)
  • Mahendra CK, Ser HL, Pusparajah P, Htar TT, Chuah LH, Yap WH, Tang YQ, Zengin G, Tang SY, Lee WL, Liew KB, Ming LC, Goh BH. Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin's Circadian Rhythm. Int J Mol Sci. 2022 Mar 7;23(5):2884. (ISI-Indexed)
  • Kang Nien How, Hazel J. Leong, Zacharias Aloysius Dwi Pramono, Kin Fon Leong, zee w. Lai, Wei H. Yap (2022). Uncovering Incontinentia Pigmenti: From DNA Sequence to Pathophysiology, Frontiers in Paediatrics Sec. Genetics of Common and Rare Diseases doi: 10.3389/fped.2022.900606 (ISI-Indexed)
  • CK Kong, LE Low, S Wei Sheng, WH Yap, PH Goh, LC Ming, A Mocan, BH Goh (2021) Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae) Frontiers in Pharmacology 11, 552453 (ISI-Indexed)
  • Ooi BK, Phang SW, Yong PVC, Chellappan DK, Dua K, Khaw KY, Goh BH, Pusparajah P, Yap WH. (2021) In vitro evaluation of the involvement of Nrf2 in maslinic acid-mediated anti-inflammatory effects in atheroma pathogenesis. Life Sci. 1;278:119658 (ISI-Indexed)
  • Lim HM, Ng CJ, Teo CH, Lee PY, Kassim PSJ, Nasharuddin NA, Yong PVC, Sellappans R, Yap WH, Lee YK, Abu Hassan ZF, Krishnan K, Ghazali SS, Idris F, Hassan N, Ayub E, Konstantinidis S, Taylor M, Poussa C, Karlgren K, Stathakarou N, Mordt P, Nilsen AT, Wharrad H. (2021) Prioritising topics for developing e-learning resources in healthcare curricula: A comparison between students and educators using a modified Delphi survey. PLOS ONE 16(6): e0253471 (ISI-Indexed)
  • Yap, WH, Teoh, ML, Tang, YQ, Goh, B-H. (2021) Exploring the use of virtual laboratory simulations before, during, and post COVID-19 recovery phase: An Animal Biotechnology case study. Biochem Mol Biol Educ. 2021; 1– 7. (ISI-Indexed)
  • Siew, W.S.; Tang, Y.Q.; Kong, C.K.; Goh, B.-H.; Zacchigna, S.; Dua, K.; Chellappan, D.K.; Duangjai, A.; Saokaew, S.; Phisalprapa, P.; Yap, W.H. Harnessing the Potential of CRISPR/Cas in Atherosclerosis: Disease Modeling and Therapeutic Applications. Int. J. Mol. Sci. 2021, 22, 8422. (ISI-Indexed)
  • Y Chan, SW Ng, JZX Tan, G Gupta, P Negi, L Thangavelu, SR Balusamy, H Perumalsamy, WH Yap, SK Singh, V Carusok, K Dua, DK Chellappann. (2021) Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy. South African Journal of Botany 143 (2021) 176-197 (ISI-Indexed)
  • Yap, W.H., Cheah, T.Y., Yong, L.C. et al. Fibroblast-derived matrices-based human skin equivalent as an in vitro psoriatic model for drug testing. J Biosci 46, 86 (2021). (SCOPUS-Indexed)
  • Mahendra, C.K.; Tan, L.T.H.; Mahendra, C.K.; Ser, H.-L.; Pusparajah, P.; Htar, T.T.; Chuah, L.-H.; Yap, W.H.; Tang, S.Y.; Ming, L.C.; Yow, Y.-Y.; Goh, B.H. The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent. Cosmetics 2021, 8, 79. (SCOPUS-Indexed)
  • Yap BJM, Lai-Foenander AS, Goh BH, Ong YS, Duangjai A, Saokaew S, Chua CLL, Phisalprapa P and Yap WH (2021) Unraveling the Immunopathogenesis and Genetic Variants in Vasculitis Toward Development of Personalized Medicine. Front. Cardiovasc. Med. 8:732369. doi: 10.3389/fcvm.2021.732369 (ISI-Indexed)
  • Phua CYH, Teoh ZL, Goh BH, Yap WH, Tang YQ. (2021) Triangulating the pharmacological properties of thymoquinone in regulating reactive oxygen species, inflammation, and cancer: Therapeutic applications and mechanistic pathways. Life Sci; 287:120120. (ISI-Indexed)
  • Goh BH, Mocan A, Xiao J, Mah SH, Yap WH. (2021) Editorial: Targeting Human Inflammatory Skin Diseases With Natural Products: Exploring Potential Mechanisms and Regulatory Pathways. Front Pharmacol. 12:791151. (ISI-Indexed)
  • Soon, T.N., Chia, A.Y.Y., Yap, W.H., Tang Y.Q. (2020). Anticancer Mechanisms of Bioactive Peptides. Protein & Peptide Letters. 27: 1-8 (ISI-Indexed)
  • Choo WT, Teoh ML, Phang SM, Convey P, Yap WH, Goh BH & Beardall J (2020). Microalgae as Potential Anti-inflammatory Natural Product against Human Inflammatory Skin Diseases. Frontiers in Pharmacology, 11:1086; doi: 10.3389/fphar.2020.01086 (ISI-Indexed)
  • SW Phang, BK Ooi, N Ahemad, WH Yap (2020) Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis. Vascular pharmacology, 128-129 (106675) (ISI-Indexed)
  • How KN, Yap WH, Lim CLH, Goh BH and Lai ZW (2020) Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review. Front. Pharmacol. 11:1105. doi: 10.3389/fphar.2020.01105 (ISI-Indexed)
  • Mahendra CK, Tan LTH, Lee WL, Yap WH, Pusparajah P, Low LE, Tang SY, Chan KG, Lee LH and Goh BH (2020) Angelicin—A Furocoumarin Compound With Vast Biological Potential. Front. Pharmacol. 11:366. doi: 10.3389/fphar.2020.00366 (ISI-Indexed)
  • S Anuwar, ML Teoh, WH Yap (2020) Effects of elevated temperatures on growth and photosynthetic performance of polar Chlorella. Adv Polar Sci 31 (2), 124-131 (SCOPUS-Indexed)
  • SM Choo, KY Yap, WH Yap, JA Ewe (2020) Soy fermentation by orally isolated putative probiotic Streptococcus salivarius for healthy oral. Journal of International Oral Health 12 (1), 33 (SCOPUS-Indexed)
  • SL Ng, TN Soon, WH Yap, KB Liew, YC Lim, LC Ming, YQ Tang, BH Goh (2020). Convalescent plasma: A Potential Therapeutic management Option forof COVID-19 patients. Asian Pacific Journal of Tropical Medicine. DOI: 10.4103/1995-7645.291408
  • Ng SL, Soon TN, Yap WH, Liew KB, Lim YC, Ming LC, et al. (2020). Convalescent plasma: A potential therapeutic option for COVID-19 patients. Asian Pac J Trop Med. 13(11): 477-486. (ISI-Indexed)
  • Ong CP, Lee WL, Tang YQ, Yap WH. Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancers 2020, 12, 48. (ISI-Indexed)
  • Gunter NV, Yap BJM, Chua CLL and Yap WH (2019) Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients. Front. Genet. 10:395. doi: 10.3389/fgene.2019.00395 (ISI-Indexed)
  • MahendraCK, Tan LTH, Yap WH, et al. An Optimized Cosmetic Screening Assay for Ultraviolet B (UVB) Protec-tive Property of Natural Products. Prog Drug Discov Biomed Sci 2019; 2(1): a00000xx
  • Tay K-C, Tan LT-H, Chan CK, Hong SL, Chan K-G, Yap WH, Pusparajah P, Lee L-H and Goh B-H (2019) Formononetin: A Review of Its Anticancer Potentials and Mechanisms. Front. Pharmacol. 10:820. doi: 10.3389/fphar.2019.00820 (ISI-Indexed)
  • Mahendra CK, Tan LTH, Yap WH, et al. Model of Experimentation for Photoprotective Properties of Natural Products Against Ultraviolet C (UVC) Damage: A Case Study On Rosmarinic Acid. Prog Drug Discov Biomed Sci 2019; 2(1): a0000027
  • Ooi BK, Ahemad N, and Yap WH. A reliable and reproducible assay for determining the effect of natural product on macrophages lipid uptake and cholesterol efflux: A case study of maslinic acid. Prog Drug Discov Biomed Sci 2019; 2(1): a0000031
  • Yap WH. Role Play in Drug Discovery and Development: Biosciences student performance and perspectives when role play experiential learning activities are integrated into learning. Prog Drug Discov Biomed Sci 2019; 2(1): a0000032
  • Tan LTH, Low LE, Tang SY, et al. A reliable and affordable 3D tumor spheroid model for natural product drug discovery: a case study of curcumin. Prog Drug Discov Biomed Sci 2018; 1(1): a0000017
  • Yap, W.H., Phang, S.W., Ahmed, N. et al. (2018). Differential effects of sPLA2-GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells, Mol Cell Biochem. pp 1–9. (ISI-Indexed)
  • Ma DSL, Tan LT-H, Chan K-G, Yap WH, Pusparajah P, Chuah L-H, Ming LC, Khan TM, Lee L-H and Goh B-H (2018) Resveratrol—Potential Antibacterial Agent against Foodborne Pathogens. Front. Pharmacol. 9:102. doi: 10.3389/fphar.2018.00102 (ISI-Indexed)
  • Yap, W.H., Ooi, B.K., Ahmed, N. et al. J Biosci (2018). Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation. Journal of Biosciences, pp 1-9 (ISI-Indexed)
  • Yong, L.C., Abdul Malek, N.F., Se Yong, E.N., Yap, W.H., Nobuyuki, M., Yoshitaka, N. (2018). Fabrication of Hydroxyapatite blended cyclic type Polylactic Acid and Poly (ε-Caprolactone) Tissue Engineering Scaffold, International Journal of Applied Ceramic Technology. DOI: 10.1111/ijac.13115 (ISI-Indexed)
  • Ooi BK, Chan K-G, Goh BH and Yap WH (2018) The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches. Front. Pharmacol. 9:1308. doi: 10.3389/fphar.2018.01308 (ISI-Indexed)
  • Ooi, B.K.; Goh, B.H.; Yap, W.H. Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation. Int. J. Mol. Sci. 2017, 18, 2336. (ISI-Indexed)
  • Yap W.H., Ahmed N., Lim Y.M. (2016). Inhibition of Human Group IIA-Secreted Phospholipase A2 and THP-1 Monocyte Recruitment by Maslinic Acid. Lipids, 51(10), pp.1153-1159 (ISI-Indexed)
  • Yap W.H., Lim Y.M. (2015). Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation. Biochemistry Research International 2015, pp.- (ISI-Indexed)
Article in Proceeding
  • Song, S. C. S., Phang, S. W., & Yap, W. H. (2019). Bioactivity evaluation of bio-hydroxyapatite derived from Spanish mackerel in composite scaffolds for bone tissue engineering. In Proceedings of the International Engineering Research Conference - 12th EURECA 2019 AIP Conference Proceedings (Vol. 2137, pp. 20015-1–10). AIP Publishing. (ISI-Indexed)
  • Phang S, Ooi B, Ahmed N and Yap W (2019). Maslinic acid suppresses macrophage foam cell formation via inhibition of LDL oxidation and cholesterol efflux. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00025 (ISI-Indexed)
(Project title),(Role),(Duration),(Level)
  • New vaccination technology via skin absorption: Elucidation of skin penetration and immunogenicity profiles of an antigen model, Co-researcher, 2022 to 2025 (National)
  • Curcumin analogues with N-methyl 4-piperidone linker suppress immune functions and MyD88-dependent NF-kB/MAPKs/ PI3-Akt signaling pathways in LPS-primed macrophages, Co-researcher, 2020 to 2024 (National)
  • Identification and evaluation of diagnostic tumour-homing peptides specifically targeting metastatic breast cancer cells using phage-displayed peptide libraries, Co-researcher, 2020 to 2024 (National)
  • Antioxidative potential amphiphile-modified low molecular weight hyaluronic acid (LMWHA) loaded with kojic acid ester (KAE) nanoemulsion, Co-researcher, 2019 to 2022 (National)
  • Unraveling the role of cellular senescence marker p16INK4a in atherosclerotic lesion fatty streaks foam cells formation, Project Leader, 2019 to 2023 (National)
  • Preparation and characterisation of polyvinyl alcohol with natural hydroxyapatite from fish bone as biocomposite nanomaterial, Co-researcher, 2018 to 2020 (Taylor's University)
  • In vitro evaluation of polar and tropical microalgae extracts as anti-oxidative and de-pigmenting agents in cosmeceutical products, Co-researcher, 2018 to 2020 (Taylor's University)
  • In silico prediction and in vitro validation of mauriporin-derived peptides as potential therapeutic anticancer agents, Co-researcher, 2018 to 2019 (Taylor's University)
  • Investigating the Modulatory Effects of Swietenia Macrophylla Seed Extracts and Limonoid Compounds in Regulating Macrophage Cholesterol Homeostasis , Project Leader, 2018 to 2020 (Taylor's University)
  • Advancing Co-creation of RLOs to Digitise healthcare curricula (ACoRD), Co-researcher, 2018 to 2022 (International)
  • Acclimatory responses of a green algae to elevated temperatures: a proteomic and bioinformatics approach, Co-researcher, 2017 to 2021 (National)
  • Evaluating the mechanism of maslinic acid in monocyte recruitment and foam cell macrophage formation: Regulatory effect of NF-kB and Nrf2, Project Leader, 2015 to 2019 (National)
  • A novel solution of arthritis - full biopolymer based bio-inspired tissue engineering cartilage , Co-researcher, 2015 to 2017 (Taylor's University)
  • Development and characterization of human fibroblast-derived matrices-based human skin equivalent as a novel in-vitro psoriatic model for drug testing, Project Leader, 2015 to 2017 (Taylor's University)
  • Development of probiotic-fermented-soy-based orally-dissolving strip for oral health, Co-researcher, 2014 to 2017 (National)
(Title of Thesis),(Name of Candidates),(Academic Level),(Role)
  • CHOO SIEW MING  (Co-supervisor (Internal))
  • PHANG SU WEN  (Main Supervisor)
  • CHEAH TOH YANG  (Main Supervisor)
  • SYAZANA BINTI ANUWAR  (Co-supervisor (Internal))
  • WONG CHING YEE  (Co-supervisor (Internal))
  • CALVIN LIM LAI HOCK  (Co-supervisor (Internal))
  • SIEW WEI SHENG  (Main Supervisor)
  • LOH ZI HAN  (Co-supervisor (Internal))
  • WAI KAI WEN  (Main Supervisor)
(Title),(Event),(Date Presented),(Organiser),(Level)
  • ASSESSING CRITICAL THINKING USING LABORATORY DATA-GENERATORS: A CASE STUDY ON CLONING OF CRISPR CONSTRUCT, International University Carnival on E-Learning, 28/06/2022 to 30/06/2022, Ministry of Higher Education, Malaysia (International)
  • Secretory Phospholipase A2-IIA-regulation of macrophage lipid accumulation by Maslinic acid a potent anti-inflammatory molecule, 43rd PSBMB Annual Convention, 05/12/2016 to 07/12/2016, The Philippine Society for Biochemistry and Molecular Biology (PSBMB) (International)
  • Fireside chat: Assessing Laboratory in an online environment: Can it be done? (Higher education: digital assessment) , Edutech Asia: Inspiring the next generation across Asia, 09/11/2021 to 11/11/2021, EduTech Asia (International)
  • Foam cell formation: Targeting macrophage lipids homeostasis and inflammation in atherosclerosis, Graduate Research Symposium 2021, 30/11/2021 to 30/11/2021, Taylor's University and Mahidol University (International)