Curriculum Vitae

PERSONAL DETAILS

Dr Yap Wei Hsum


ADMINISTRATIVE DUTIES
(Role),(Level),(Duration)
  • Senior Lecturer II, Faculty of Health & Medical Sciences, 17/05/2013 to present
ACADEMIC QUALIFICATION
(Qualification),(Institution)
  • Doctor of Philosophy (Science), UNIVERSITY TUNKU ABDUL RAHAMAN, Malaysia
  • Bachelor of Science (Hons) in Biotechnology, UNIVERSITI TUNKU ABDUL RAHMAN, Malaysia
  • PGCHeTL, TAYLOR'S UNIVERSITY, Malaysia
AREAS OF EXPERTISE
(Area)
  • Molecular Pharmacology
RESEARCH INTEREST
(Research Area)
  • Macrophage foam cells
  • Skin models
PUBLICATIONS
(Title of publication in APA style)
Book Chapter
2020
  • Neo, Y. P., & Yap, W. H. (2020). Teach Less, Learn More: A Paradigm Through Collaborative Learning in Science. In P. Kumar, M. Keppell, & C. Lim (Eds.), Preparing 21st Century Teachers for Teach Less, Learn More (TLLM) Pedagogies (pp. 10-29). Hershey, PA: IGI Global. doi:10.4018/978-1-7998-1435-1.ch002
  • Zee-Wei, L. and Wei-Hsum Yap (2020). Promoting Role Play Simulation Activities in Sciences-based Modules. In P. Kumar, M. Keppell, & C. Lim (Eds.), Preparing 21st Century Teachers for Teach Less, Learn More (TLLM) Pedagogies. (pp.125-141). Hershey, PA: IGI Global. DOI: 10.4018/978-1-7998-1435-1.ch008
2018
  • Yap, W. H. (2018). Supporting Group Learning Using Collaborative Networked Platforms. In S. Tang, & C. Lim (Eds.), Preparing the Next Generation of Teachers for 21st Century Education (pp. 144-164). Hershey, PA: IGI Global. doi:10.4018/978-1-5225-4080-9.ch009
Article in Journals
2020
  • How KN, Yap WH, Lim CLH, Goh BH and Lai ZW (2020) Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review. Front. Pharmacol. 11:1105. doi: 10.3389/fphar.2020.01105 (ISI-Indexed)
     
  • Mahendra CK, Tan LTH, Lee WL, Yap WH, Pusparajah P, Low LE, Tang SY, Chan KG, Lee LH and Goh BH (2020) Angelicin—A Furocoumarin Compound With Vast Biological Potential. Front. Pharmacol. 11:366. doi: 10.3389/fphar.2020.00366 (ISI-Indexed)
     
  • Choo WT, Teoh ML, Phang SM, Convey P, Yap WH, Goh BH & Beardall J (2020). Microalgae as Potential Anti-inflammatory Natural Product against Human Inflammatory Skin Diseases. Frontiers in Pharmacology, 11:1086; doi: 10.3389/fphar.2020.01086 (ISI-Indexed)
     
  • SW Phang, BK Ooi, N Ahemad, WH Yap (2020) Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis. Vascular pharmacology, 128-129 (106675) (ISI-Indexed)
     
  • SM Choo, KY Yap, WH Yap, JA Ewe (2020) Soy fermentation by orally isolated putative probiotic Streptococcus salivarius for healthy oral. Journal of International Oral Health 12 (1), 33 (SCOPUS-Indexed)
     
  • S Anuwar, ML Teoh, WH Yap (2020) Effects of elevated temperatures on growth and photosynthetic performance of polar Chlorella. Adv Polar Sci 31 (2), 124-131 (SCOPUS-Indexed)
     
  • SL Ng, TN Soon, WH Yap, KB Liew, YC Lim, LC Ming, YQ Tang, BH Goh (2020). Convalescent plasma: A Potential Therapeutic management Option forof COVID-19 patients. Asian Pacific Journal of Tropical Medicine. DOI: 10.4103/1995-7645.291408
  • Ong CP, Lee WL, Tang YQ, Yap WH. Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancers 2020, 12, 48. (ISI-Indexed)
     
2019
  • Gunter NV, Yap BJM, Chua CLL and Yap WH (2019) Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients. Front. Genet. 10:395. doi: 10.3389/fgene.2019.00395 (ISI-Indexed)
     
  • MahendraCK, Tan LTH, Yap WH, et al. An Optimized Cosmetic Screening Assay for Ultraviolet B (UVB) Protec-tive Property of Natural Products. Prog Drug Discov Biomed Sci 2019; 2(1): a00000xx
     
  • Tay K-C, Tan LT-H, Chan CK, Hong SL, Chan K-G, Yap WH, Pusparajah P, Lee L-H and Goh B-H (2019) Formononetin: A Review of Its Anticancer Potentials and Mechanisms. Front. Pharmacol. 10:820. doi: 10.3389/fphar.2019.00820 (ISI-Indexed)
     
  • Mahendra CK, Tan LTH, Yap WH, et al. Model of Experimentation for Photoprotective Properties of Natural Products Against Ultraviolet C (UVC) Damage: A Case Study On Rosmarinic Acid. Prog Drug Discov Biomed Sci 2019; 2(1): a0000027
     
  • Ooi BK, Ahemad N, and Yap WH. A reliable and reproducible assay for determining the effect of natural product on macrophages lipid uptake and cholesterol efflux: A case study of maslinic acid. Prog Drug Discov Biomed Sci 2019; 2(1): a0000031
     
  • Yap WH. Role Play in Drug Discovery and Development: Biosciences student performance and perspectives when role play experiential learning activities are integrated into learning. Prog Drug Discov Biomed Sci 2019; 2(1): a0000032
     
2018
  • Tan LTH, Low LE, Tang SY, et al. A reliable and affordable 3D tumor spheroid model for natural product drug discovery: a case study of curcumin. Prog Drug Discov Biomed Sci 2018; 1(1): a0000017
     
  • Yap, W.H., Phang, S.W., Ahmed, N. et al. (2018). Differential effects of sPLA2-GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells, Mol Cell Biochem. pp 1–9. (ISI-Indexed)
  • Ma DSL, Tan LT-H, Chan K-G, Yap WH, Pusparajah P, Chuah L-H, Ming LC, Khan TM, Lee L-H and Goh B-H (2018) Resveratrol—Potential Antibacterial Agent against Foodborne Pathogens. Front. Pharmacol. 9:102. doi: 10.3389/fphar.2018.00102 (ISI-Indexed)
     
  • Yap, W.H., Ooi, B.K., Ahmed, N. et al. J Biosci (2018). Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation. Journal of Biosciences, pp 1-9 (ISI-Indexed)
  • Yong, L.C., Abdul Malek, N.F., Se Yong, E.N., Yap, W.H., Nobuyuki, M., Yoshitaka, N. (2018). Fabrication of Hydroxyapatite blended cyclic type Polylactic Acid and Poly (ε-Caprolactone) Tissue Engineering Scaffold, International Journal of Applied Ceramic Technology. DOI: 10.1111/ijac.13115 (ISI-Indexed)
     
  • Ooi BK, Chan K-G, Goh BH and Yap WH (2018) The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches. Front. Pharmacol. 9:1308. doi: 10.3389/fphar.2018.01308 (ISI-Indexed)
     
2017
  • Ooi, B.K.; Goh, B.H.; Yap, W.H. Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation. Int. J. Mol. Sci. 2017, 18, 2336. (ISI-Indexed)
     
2016
  • Yap W.H., Ahmed N., Lim Y.M. (2016). Inhibition of Human Group IIA-Secreted Phospholipase A2 and THP-1 Monocyte Recruitment by Maslinic Acid. Lipids, 51(10), pp.1153-1159 (ISI-Indexed)
     
2015
  • Yap W.H., Lim Y.M. (2015). Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation. Biochemistry Research International 2015, pp.- (ISI-Indexed)
     
Article in Proceeding
2019
  • Song, S. C. S., Phang, S. W., & Yap, W. H. (2019). Bioactivity evaluation of bio-hydroxyapatite derived from Spanish mackerel in composite scaffolds for bone tissue engineering. In Proceedings of the International Engineering Research Conference - 12th EURECA 2019 AIP Conference Proceedings (Vol. 2137, pp. 20015-1–10). AIP Publishing. https://doi.org/10.1063/1.5120991 (ISI-Indexed)
     
2018
  • Phang S, Ooi B, Ahmed N and Yap W (2019). Maslinic acid suppresses macrophage foam cell formation via inhibition of LDL oxidation and cholesterol efflux. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00025 (ISI-Indexed)
RESEARCH PROJECT
(Project title),(Role),(Duration),(Level)
  • Antioxidative potential amphiphile-modified low molecular weight hyaluronic acid (LMWHA) loaded with kojic acid ester (KAE) nanoemulsion, Co-researcher, 2019 to 2021 (National)
  • Unraveling the role of cellular senescence marker p16INK4a in atherosclerotic lesion fatty streaks foam cells formation, Project Leader, 2019 to 2022 (National)
  • In vitro evaluation of polar and tropical microalgae extracts as anti-oxidative and de-pigmenting agents in cosmeceutical products, Co-researcher, 2018 to 2020 (Taylor's University)
  • In silico prediction and in vitro validation of mauriporin-derived peptides as potential therapeutic anticancer agents, Co-researcher, 2018 to 2019 (Taylor's University)
  • Preparation and characterisation of polyvinyl alcohol with natural hydroxyapatite from fish bone as biocomposite nanomaterial, Co-researcher, 2018 to 2020 (Taylor's University)
  • Investigating the Modulatory Effects of Swietenia Macrophylla Seed Extracts and Limonoid Compounds in Regulating Macrophage Cholesterol Homeostasis , Project Leader, 2018 to 2020 (Taylor's University)
  • Acclimatory responses of a green algae to elevated temperatures: a proteomic and bioinformatics approach, Co-researcher, 2017 to 2020 (National)
  • Unraveling the role of complement receptor 3 (CR3) in the clearance of malaria-infected erythrocytes, Co-researcher, 2015 to 2018 (National)
  • A novel solution of arthritis - full biopolymer based bio-inspired tissue engineering cartilage , Co-researcher, 2015 to 2017 (Taylor's University)
  • Development and characterization of human fibroblast-derived matrices-based human skin equivalent as a novel in-vitro psoriatic model for drug testing, Project Leader, 2015 to 2017 (Taylor's University)
  • Evaluating the mechanism of maslinic acid in monocyte recruitment and foam cell macrophage formation: Regulatory effect of NF-kB and Nrf2, Project Leader, 2015 to 2019 (National)
  • Development of probiotic-fermented-soy-based orally-dissolving strip for oral health, Co-researcher, 2014 to 2017 (National)
SUPERVISION
(Title of Thesis),(Name of Candidates),(Academic Level),(Role)
COMPLETED
  • THE ROLE OF p53 IN 2-METHOXY 1,4-NAPTHOQUINONE (MNQ) INDUCED CELL CYCLE ARREST AT G2/M IN AN OSTEOSARCOMA (U-2OS) CELL LINE., CHARMAINE PATRICIA IGNATIUS  (Co-supervisor (Internal))
ONGOING
  • CHOO SIEW MING  (Co-supervisor (Internal))
  • PHANG SU WEN  (Main Supervisor)
  • OOI BEE KEE  (Main Supervisor)
  • CHEAH TOH YANG  (Main Supervisor)
  • SYAZANA BINTI ANUWAR  (Co-supervisor (Internal))
  • CALVIN LIM LAI HOCK  (Co-supervisor (Internal))
  • SIEW WEI SHENG  (Main Supervisor)
PRESENTATION
(Title),(Event),(Date Presented),(Organiser),(Level)
ORAL PRESENTER
  • Secretory Phospholipase A2-IIA-regulation of macrophage lipid accumulation by Maslinic acid a potent anti-inflammatory molecule, 43rd PSBMB Annual Convention, 05/12/2016 to 07/12/2016, The Philippine Society for Biochemistry and Molecular Biology (PSBMB) (International)